Saturday, September 7, 2019

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What is Contamination? How to Prevent Foodborne Contamination?


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What is Safe Food?

Safe food; has maintained its nutritional value, microbiological, physically and chemically clean and does not contain harmful substances in health. Factors causing food contamination endanger food safety. For this reason, nutrients; from planting to harvesting, from production to consumption.
Foods Undergo Contamination in 3 Ways:

Physical Pollution: Pollution caused by non-food impurities. Fractures such as broken glass, metal, hair, nails and flies cause physical contamination.
Chemical Pollution: Chemical contaminants. Examples of chemical contamination include contamination of metals from the container in which the food is stored, detergents or residues transmitted from poorly rinsed containers, pesticides, dyestuffs dissolved in packaging, and the use of food additives used above.
Biological Pollution: Toxins naturally occurring in the content of food such as poisonous honey , mycotoxins, sprouted and greened potatoes are the pollution caused by not keeping the nutrients in proper conditions, hygiene is not provided completely and consequently the most important and widespread biological pollution is the microorganism growth.

Among the microorganisms, bacteria are the most endangering food safety, causing poisoning and diseases. The greatest danger in this regard is the rapid growth of the infected bacteria by finding the appropriate condition and duration. Reproductive bacteria then cause large-scale pollution and disease. The fact that they are not seen by the eye and the contamination rapidly makes this a much bigger problem.
What are the sources of contamination?

Foods contaminated with harmful substances from various sources are contaminated before being brought into the kitchen or during the production phase. In other words, food is contaminated .

Contamination is the transmission of undesirable harmful substances or microorganisms in various ways. Major sources of contamination ; insects, litter, pests, dust, soil, humans, meat, milk , eggs and water. Conditions such as hair, nails, skin wounds and lack of hygiene contribute to the human being's source of contamination in many ways. If measures are not taken and hygiene is not provided against these factors, foodborne diseases are likely to occur.

What are Foodborne Diseases?

Foodborne diseases are poisonings and infections caused by consumption of any food or beverage. Microorganisms contaminated from various sources in the period from production to consumption of food multiply rapidly in favorable conditions, deteriorating the sensory quality of foods and cause foodborne diseases. Preventing this situation, which is an important health problem in many countries, can be achieved by evaluating and preserving food hygiene in every aspect.

Especially the areas where the food is prepared, the food itself and the cleaning of the equipment used are of great importance in microbial contamination. Microorganisms cannot move on their own and require a variety of mediators for contamination to occur. These agents are humans or animals. Bacteria can also choose a non-nutrient-containing substance as a source of contamination . Infections that occur in this way are called ' cross contamination '. In particular, tools and equipment used during food preparation are the most common sources of cross-contamination . Examples of cross-contamination sources include cutting boards, mixers, ambient air, kitchen worktops and clothing.

Providing food hygiene; personal hygiene during purchasing, storage methods, preparation and cooking of food, service and preparation are of great importance.

Considerations;

At the time of purchase, reliable sources should be identified, avoiding potentially risky foods such as street milk, sensory properties in meats, and labels of packaged products must be read.
The use of appropriate containers and packages during the storage of food, especially the clear storage of potential carriers such as eggs, poses a great risk for cross-contamination . It is necessary to ensure proper temperatures, to store food separately and to prevent cross-contamination , and to store food temperatures.
During the preparation of foods, washing with plenty of water, raw and cooked foods should be processed in separate vehicles, the thawed food should not be frozen again and the tools that come into contact with fish and meat, especially raw chicken, should be washed with plenty of water and detergent. Hygiene of boards where potential bacterial carriers such as raw chickens are cut is of great importance in preventing cross-contamination. During the preparation of the food, the personal hygiene of the attendant and the light colored and clean clothes are important points to be considered. Washing dishes is of great importance in the prevention of cross-contamination . Garbage should be kept away from the area where the food is prepared and stored in suitable containers. In addition, the removal of bacteria, especially the cross-contamination is essential in the prevention of flour. Raw meat and chicken are important nutrients to be considered in terms of cross-contamination of eggs. In particular, the rules for the use of equipment shall be useful in preventing cross-contamination .

Bacillus cereus: Common bacteria in cereal group. Risky foods are corn flour, pasta and rice .
Brucella spp: Animal meats, milk and cheese are also common bacteria. Care must be taken to apply pasteurization for protection.
Staphylococcus aureus: A pathogenic bacterium that resides in the skin and mucosa of humans and animals. Skin infections and foodborne diseases are frequently encountered in humans. It is known that sepsis is a common cause especially in hospitals and nurseries.
Camphylobacter jejuni: Especially poultry, birds, cattle, drinking water and mussels are also found. Risky foods include unpasteurized milk and chlorinated water.
Listeria monocytogenes: It is widely known in the environment. Raw meat and poultry, mayonnaise salads, cheese and cream are common foods for contamination. Pasteurization process should be considered.
Salmonella: Especially raw chicken and eggs, raw salads and meat products are risky foods. Cracked, cracked eggs should not be used.

These bacteria are common pathogens. Diseases are seen as a result of toxic contamination of bacteria. Compliance with these issues that must be observed during the purchase, preparation and presentation of foods will prevent the consumer from confronting them. Ensuring food safety is of great importance.


22AXX
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Disinfection Control: How to Select and Control Disinfectant Solutions?


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Sterilization, decontamination and disinfection form the basis of the infection control program. Procedures to prevent cross-infection must be performed on vehicles used repeatedly for diagnostic and therapeutic purposes. It should be kept in mind that the insufficiency of sterilization and disinfection of medical devices may lead to extra treatment expenditures, more importantly morbidity and mortality in the patient, unnecessary procedures for sterilization-disinfection will increase hospital expenses and cause selection of resistant microorganisms.

The most suitable option for cross-contamination prevention is disposable, single-use tools. However, it is not always possible to use disposable instruments because some vehicles are too expensive or the vehicle cannot be disposed of. If the medical and surgical interventions cannot be obtained as a disposable device, the first method of sterilization or disinfection is heat. However, plastics, rubber, silk, electronic devices and so on. materials can not be used in heat, irradiation sterilization can not be provided, disinfectants are used.

Disinfectants are divided into two groups as gas and liquid. The effectiveness of the disinfectants is influenced by the cleaning process before disinfection, the type of microorganism, the level of contamination and the type of disinfectant, the concentration of germicidine used, the duration of application, the physical configuration of the object (whether a narrow canal or slit, etc.), and the temperature and pH during the process. It is of no use to keep a vehicle in the disinfectant longer than recommended. This may cause irreversible damage to the vehicle.

Before using disinfectant, cleaning should be used as much as possible. The device and the surface to be treated should be washed with hot water and detergent if possible. It has been experimentally demonstrated that 99.99% or 4 log of viruses and vegetative bacteria are reduced by this process. In addition, these residues cause the disinfectant not to reach the microorganism or react with organic substances to lose its activity.

Ethylene oxide gas disinfectant is generally used for instruments to be sterilized. It is the most commonly used sterilization method after heat. It can be used safely in sterilization of fine hole and narrow groove instruments due to its higher penetration ability compared to liquids. Sterilization with ethylene oxide is carried out in about four hours, but for about 12 hours or more, it is expected to remove the toxic oxide ethylene. It should be noted that ethylene oxide is an explosive, carcinogenic and toxic gas.

Gas plasma has been developed as an alternative to sterilization with ethylene oxide. Plasma is, as we know it, a liquid medium containing free ions. Germicidal chemical agent is ionized with radio waves under vacuum and mixed with air is called gas plasma. Plasma form is also called the fourth state of matter. Hydrogen peroxide is a strong germicidal agent with sporicidal activity in liquid form. The gas plasma obtained from hydrogen peroxide has germicidal activity to provide sterilization. Hydrogen peroxide in the form of gas plasma has no corrosive effect. Active ions lose energy as they kill microorganisms and become completely non-toxic products by removing ionizing waves and vacuum. The use of gas plasma sterilization techniques using chlorindioxide, ozone, ethyl alcohol, peracetic acid and various mixtures of these substances is under investigation and some of them have begun to be used. Sterilization is achieved in as little as thirty-sixty minutes. However, it can be used for sterilization of small volume devices. The packages should not be made of paper and fabric, but made of polyethylene or propylene.

The practical side of the method is that it does not require a special tool for the use of liquid disinfectants. The degree of activity is different. In addition, the response of microorganisms to disinfectants is different. Very little disinfectant, known as chemical sterilizer, removes all microorganisms including spores in as long as six to eight hours. At the same concentration, it kills all microorganisms except for some bacterial spores in a much shorter period (20-30 minutes). Therefore, these disinfectants are also called high-level disinfectants. Although there is no sporicidal activity, disinfectants with tuberculocidal activity are defined as moderate disinfectants, but disinfectants with no tuberculocidal activity, but with HIV-including virucidal activity are defined as low-level disinfectants ( Figure 1 ).

The tools used in the hospital vary according to the risk of infection. The choice of disinfection method is determined by the level of infection risk of the vehicles. According to this;

1. Critical means: Direct contact with normally sterile tissues, body cavities and body fluids.

2. Semi-critical tools: Those who come into contact with the mucous membranes but do not penetrate the body.

3. Non-critical tools and substances: Those who do not come into direct contact with the person or who only come into contact with intact skin.

The availability of critical devices depends on their sterility. Many such instruments are either disposable or heat-sterile. However, as described above, heat cannot always be applied for some reason.

The next method to be proposed is sterilization with gas disinfectants (eg ethylene oxide, gas plasma method). Besides being an effective method, it is important for sterilizing large instruments that cannot be immersed in disinfectants. It is conceivable to wipe such instruments with disinfectant, but this applies to semi-critical and non-critical vehicles. In addition, some vehicles may be damaged if left in disinfectants for a long time. Liquid disinfectants are most commonly used in gluteraldehyde, formaldehyde, chlorindioxide, hydrogen peroxide or formulas. The most commonly used formulations are 7.5% hydrogen peroxide in addition to 2% gluteraldehyde, peracetic acid in less than 1% concentration, or combinations of 0.08% peracetic acid and 1% hydrogen peroxide. Sporocidal activity can only be achieved by prolonged application of an effective disinfectant to bacterial spores (6-20 hours depending on the type of disinfectant). Orthophitalaldehyde, which has been approved by the Food and Drug Administration (FDA) in recent years, is a high level disinfectant used in American and European countries. It does not need to be activated for use, is less irritant to the eye and respiratory tract, and has no advantage over gluteraldehyde in terms of sporicidal activity, but the effect on mycobacteria is much earlier.

The instrument is washed three times with sterile distilled water after treatment with disinfectants. It is then dried with a sterile towel using sterile gloves and made ready for use.

At the end of these procedures, the bacterial spore may remain. However, their number has decreased considerably and they are particularly spores of saprophyte microorganisms. These microorganisms are destroyed by body resistance. However, this idea is not always valid. Even the Bacillus subtilis , known as nonpathogenic, can cause serious lethal infections where the resistance of the host is low, such as immunodeficient or immunosuppressed patients.

Sterilization of vehicles contaminated with Creutzfeldt-Jakob prion cannot be achieved by normal procedures. Vehicles with high risk for prion, such as the brain, dura material or cornea, should be treated with 1 N NaOH at room temperature after sterilization for 30 minutes at 132 ° C or alternatively for 30 minutes at 121 ° C. “Centers for Disease Control and Prevention (CDC) alternatif has introduced a practical approach as an alternative and reported that after cleaning the vehicle, a pre-vacuum sterilizer is sufficient for 18 minutes at 132-134 ° C and one hour at 121 ° C. Normal sterilization programs have been recommended by CDC for contamination with organs such as cerebrospinal fluid, spleen, kidney, lymph node. For non-critical vehicles, 15 minutes of treatment with 1 N NaOH at room temperature is sufficient.

In disinfection of semi-critical devices, it is aimed to kill all microorganisms except bacterial spores. Some of the spores are devastated when these operations are performed.

Here, if the structure of the substance is appropriate; heat sterilization or disinfection at 75 ° C for 30 minutes at humid temperature is preferred. High-level disinfectants are generally used in the disinfection of semi-critical vehicles, with phenol compounds, iodophores, chlorine compounds being preferred from intermediate disinfectants. Flexible fiber-optic endoscope, laryngoscope, vaginal speculae, anesthesia respiratory circulation devices, ophthalmic instruments and some dental instruments (amalgam condenser) are in this group.

Cross-contamination is frequently observed with medical devices such as flexible endoscope, bronchoscope, arthroscope. In the clinical course ranging from asymptomatic colonization to death, as a result of gastrointestinal endoscopy, Salmonella and Pseudomonas aeruginosa ; Mycobacterium tuberculosis , atypical Mycobacteria , P. aeruginosa are the most common infections after bronchoscopy. The biggest problem is hepatitis C and multidrug resistant M. tuberculosis after bronchoscopy. Transcontamination with endoscopes is most commonly observed after retrograde cholangiopancreatography. The most common causes are inadequate pre-cleaning, poor selection of disinfectants, deficiencies and inaccuracies in disinfection procedures. Hypochlorite, iodophore and phenol derivatives should not be used against the risk of damage to such valuable instruments and gluteraldehyde, hydrogen peroxide, peracetic acid, orthophitalaldehyde or derivatives should be used. Although it is theoretically known to leave in 2.4% gluteraldehyde solution for 45 minutes at 25 ° C for high-level disinfection, after 20 minutes of use of an FDA-approved sterilized effective disinfectant with a temperature of 20 ° C for bronchoscopes after the FDA standard cleaning protocol, to achieve high level disinfection It was sufficient for. In recent years, the use of orthophitalaldehyde for high-level disinfection has become widespread, with the use of orthophitalaldehyde at a concentration of 0.55% at 20 ° C for 12 minutes in the United States, 10 in Canada, and five minutes in Europe, Asia and Latin America. it is indicated.

In recent years, the use of both washing and disinfection tools has become widespread. Peracetic acid (Steris System I) is used as the high level disinfectant in these devices which have been FDA approved and these devices are used for disinfection of endoscopes.

After disinfection, it is preferred to wash the semi-critical means with sterile distilled water. Non-tuberculous mycobacteria and Legionella contamination from tap water may occur. In case tap water is used, the device is re-disinfected with alcohol, allowed to dry and ready for use.

Hepatitis viruses and HIV do not resist medium disinfection. However, in the case of contamination with these viruses, a high level of disinfection is recommended for semi-critical means.

The low-level disinfection application for non-critical devices aims to kill vegetative forms of bacteria and lipid-containing viruses. The instruments in this group can be divided into two groups as low risk and minimal risk. Materials such as beds, bed sheets, which come into contact with intact skin, fall into the low risk group and if it is not contamination, it is sufficient to disinfect them by means of heat and water (wash with hot water, etc.) and moderate disinfection is required.

For minimal risk vehicles and floors that do not come into contact with intact skin, cleaning with detergent water is sufficient and low level disinfection is applied. Disinfectants can be used in case of contamination by the patient's body interests. Lower concentrations of hypochlorite, iodophores and phenol compounds can be used from quaternary ammonium compounds from low-level disinfectants or from mid-level disinfectants. In this type of disinfection, 10 minutes of application is sufficient. In addition, 70-80% alcohol is useful for rapid disinfection of aerosol-contaminated surfaces, such as in dentistry.

The number of disinfectants used in the hospital should be minimized as much as possible. Those who have been approved by serious institutions (FDA approval, CE marking), whose efficacy has been determined both in the country of manufacture and in the microbiology laboratories of the marketed country should be preferred. In addition, the disinfectant planned to be taken should be evaluated in terms of its practicality, degree of irritation and its corrosive effect, and the most appropriate choice should be made in consultation with the centers that use the disinfectant before intake ( Table 1 ). The use of unnecessary disinfectant causes economic losses as well as the selection and colonization of resistant pathogenic strains due to disinfectants used.

The efficiency of heat and gas sterilization can be routinely investigated. However, there is no routine method for determining the effectiveness of liquid disinfectants. Therefore, full compliance with the literature-supported package insert of the chemical disinfectant to be used will provide an effective disinfection.

Disinfectant solutions should be freshly prepared. The toxicity, odor and activity of the disinfectant are important and disinfectants that change odor and color should not be used. Some disinfectants are known to react with detergents. If the environment is wet after this process should be dried. Any material left wet forms a favorable environment for the growth of microorganisms.

DISINFECTION OF HOSPITAL ENVIRONMENT

Washing with water and detergent is considered to remove 80% of the microorganisms. If disinfectant is used, this ratio reaches 90-95%. Whether or not disinfectant is used in a circulating intensive hospital, the number of microorganisms in the ground will return to the previous level within one to two hours. Therefore, if there is any contamination; In hospital disinfection, it is sufficient to clean the environment with plenty of detergent water (which is preferred to be hot) which is changed frequently. The situation in ICU and operating room is not much different. It is not important to place disinfectant-wetted mats and shoe covers on the entrance doors of such units. Transmission of manual infection is a priority. Drying the environment after cleaning is more effective than disinfectants in preventing the growth of microorganisms.

The floor contaminated with blood and other materials of the patient should be disinfected after wiping with detergent water. Hepatitis B virus (HBV) can survive for one week in dry conditions under appropriate conditions. However, it is very sensitive to disinfectants. In practice it is recommended to use hypochlorite solutions as surface disinfectants and liquid soap as detergents. CDC recommends pouring 1/100 dilution hypochlorite (5000 ppm) onto the decontaminated area with blood and allowing it to stand for 10 minutes.

Disinfectant can be used after cleaning the surfaces which are in constant contact such as benches and tables in the hospital. Hypochlorite can be used in room disinfection after discharge from patients infected with methicillin-resistant S. aureus (MRSA) and similar pathogen agents in addition to viruses. Alcohol solutions containing 70% alcohol are used for disinfection of these surfaces. Although microorganisms cannot enter the body through intact skin, contamination from wounds and fractures can occur. This is one of the reasons why staff working in hemodialysis and serology units have more frequent HBV infections than the normal population.


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What is bacterial vaginosis?


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Bacterial vaginosis , a type of infectious disease, is caused by the growth of bacteria that accumulate in the vagina. If you want to know more about bacterial vaginosis and you are wondering what bacterial vaginosis is , you can look at the information we have prepared for you.

Bacterial vaginosis shows itself in the form of discharge in the vagina. Vaginal discharge occurs as a result of the accumulation of bacteria in that area. Bacteria growing in the region of the Vahina grows over time, causing bacterial vaginosis disease.

What is bacterial vaginosis?

Bacterial vaginosis is not a dangerous condition, but may cause discomforting symptoms later. that is, any woman with vaginal discharge should be investigated for gynecological examination.

How often do women experience bacterial vaginosis?

Bacterial vaginosis is more common in women than fungal infections. Nearly half of women experience bacterial vaginosis infection at least once in their lifetime.

Is bacterial vaginosis risky?

It is important to make a definitive diagnosis from bacterial non-specific vaginitis infections. Otherwise, this infection can cause permanent diseases and cause various diseases.
These diseases are as follows;

Infertility
Complications of pregnancy
Pelvic Inflammatory Disease
It can cause such diseases.

What are the symptoms of bacterial vaginosis and what are the symptoms?


Bacterial vaginosis is manifested in the form of discharge. However, the color of the stream becomes slightly different. The discharge in bacterial vaginosis is dark brown and occasionally aqueous.
People with this infectious disease say that the odor that occurs in the stream is at stale fishy smell '.

At the same time, itching and discharge in the vagina is another important symptom of the disease.

What causes bacterial vaginosis?

It is not known why bacterial vaginosis usually occurs. However, people with this infectious disease were investigated and as a result of the study, it was observed that the people who developed bacterial vaginosis had smoked, used too much antibiotics, and the vaginal douching was done continuously.

Does bacterial vaginosis spread to other people?

Bacterial vaginosis is generally not known as an infectious disease, but its infectivity is not fully understood. However, having sexual intercourse with multiple people is one of the most important factors triggering this disease.

If you have complaints of burning in your urinary tract and are constantly suffering from discharge, you can also remedy these complaints naturally. Bacterial vaginosis, disease before the formation of a number of methods that we can give you to resolve this infectious disease.

Here are natural methods to prevent bacterial vaginosis disease ...

Home yogurt method
Home yogurt cooking and regional application of yogurt has been proven to fight infection. This treatment gives similar results to clindamycin.

Apple cider vinegar method
Pour 2 cups of apple cider vinegar into a bathtub filled with warm water. You can wait for about 20 minutes in this water.

Garlic method
You can eat garlic against this disease and apply it directly to the infected area. In both trials, the pathway will be sufficient to help combat bacteria and fungi by changing vaginal pH levels.

Garlic method :

Garlic will protect you from external microbes, protecting you from infections.

Oregano method
Mix a few drops of oregano oil and a few drops of coconut oil to avoid bacterial vaginosis or infections of the vagina. You can then apply this mixture to the area of ​​infection with the help of cotton.

What is the medical treatment of bacterial vaginosis?

Antibiotic treatment is applied in medicine for bacterial vaginosis. A few antibiotics are routinely used. In addition, vaginal cream treatment is recommended and the dosage of the drugs can be increased or decreased according to the course of treatment.


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Turkey Journal of Medical Sciences


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Physical and Chemical Methods for Protection from Infection in Hematology-Oncology Clinics
NOSOCOMIAL INFECTIONS IN HEMATOLOGY AND ONCOLOGY: PREVENTIVE MEASURES: REVIEW

SUMMARY
Nasocomial infections which is an important problem for hospitalized patients and hospital staff, treatment and precautions to be taken are examined under 6 titles in this article. Nasocomial infections are nosocomial infections that occur after hospitalization and do not have an infection before hospitalization. They are most commonly seen as urinary tract infections, surgical site infections, bacteremia and pneumonia. Immunodeficiency and nosocomial infections develop in patients with hematologic and oncologic malignancies treated with chemotherapy or radiotherapy. Infections also occur in patients who develop neutropenia after chemotherapy. Severe nosocomial infections develop in patients receiving immunosuppressive therapy, undergoing splenectomy and bone marrow transplantation. Isolation practices play an important role in the control of nosocomial infections. Isolation applications are applied in two ways as isolation according to the disease and category. Insulation by category; complete isolation, contact isolation, respiratory isolation, Tbc isolation, enteric measures, drainage-secretion prevention, blood and body fluids prevention. Standard measures in practice are applied to reduce the risk of contamination of blood and body fluid-borne pathogens. In addition, contact measures, droplet measures, respiratory measures, including isolation-related prevention measures are applied. Tbc control measures emphasized the need for serious applications to prevent the spread of vancomycin resistance in hospitalized patients. Intravenous catheters are used to administer chemotherapy and fluid in hospitalized patients and may cause catheter infections in patients. Prevention of catheter infections, treatment of infections and antibiotics are emphasized. Another precaution is HEPA filters that prevent air contamination in neutropenic patient rooms. The chemical products used in hand antisepsis in hospitals are alcohol, chlorhexidine gluconate, hexachlorophene, iodine and iodophores, para-chlorine-meta-xylenol and triclosan. It is possible to determine the disinfection method according to the infection risk of the patient care materials used in the hospital environment. It is possible to collect the areas that can be taken into daily disinfection applications in 3 groups. These are the floors that are infected with the hospital floor, blood and other material of the patients, as well as benches-tables. Disinfectant is generally not required for cleaning surfaces that are regularly cleaned in hospitals, such as floors, walls, toilets, bathrooms and door handles and which do not present an infection risk.

Keywords : Infection, immunocompromised patient, neutropenia, isolation, antisepsis
ABSTRACT
Nosocomial infections, a problem of dire effects, and health care staff, are discussed at length, with emphasis on preventive measures and treatment modalities. Nosocomial infections often develop after hospitalization. They most frequently manifest as urinary and surgical infections, bacteremia and pneumonia. In patients with hematological and oncological malignancies undergoing chemotherapy or radiotherapy, immunodeficiency is not uncommon and associated hospital infections may develop. Severe infections may also be subject to immunosuppressive treatment, splenectomy and bone marrow transplantation. Isolation procedures play an important role in the control of hospital infections. Such procedures are customarily applied in two forms: disease-based isolation and category-based isolation. The latter includes full, contact, and respiratory isolation (eg, Tbc), as well as drainage-secretion, blood and other body fluid containment measures. These practical measures are aimed at diminishing the risk of contamination through fluid and airborne pathogens. It is emphasized that stringent procedures are applied under the tuberculosis control methods to avoid strengthening resistance to vancomycin in hospitalized patients. Intravascular catheters are often used for chemotherapy and fluid replacement, which frequently results in catheter-induced infections. The prevention and treatment of such infections. HEPA filters that prevent air contamination in neutropenic patient rooms. Chemical products used for antisepsis in hospitals include alcohol, chlorohexidine, gluconate, hexachlorophene, iodine and iodophores, para-chloro-meta-xylenol and triclosan. A determination of the disinfection method to be employed is often considered possible. However, the potential foci for daily disinfection procedures may be classified into three groups: such as desks and chairs. No special disinfectant is usually needed in the hospital, as well as floors, walls, WC, bathroom and door handles that are regularly serviced and do not carry a heightened risk of infection.


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How to Prevent Infections in Intensive Care ?


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Intravascular catheters are widely used especially in intensive care units for fluid replacement, parenteral nutrition, blood and blood product transfusion, drug applications and hemodynamic monitoring. However, catheter use causes infectious and noninfectious complications. The risk of catheter infection is 1-2 / 1,000 catheter days. Intravascular catheter infections are important causes of morbidity and mortality. Coagulase-negative staphylococci, Staphylococcus aureus, enterococci, aerobic gram-negative bacilli and Candida albicans are the most common microorganisms that cause catheter infection [1] . The treatment of catheter infection varies according to the catheter used, the type of infection developed and the causative microorganism [2] . Therefore, the definition should be made well ( Table 1 ) [1-4] .

DIAGNOSIS

Clinical Diagnosis

The sensitivity and specificity of the clinical findings are low in catheter infection. Catheter infections are clinically seen as skin infection, subcutaneous tunnel infection, thrombophlebitis, bacteremia, sepsis, infective endocarditis, metastatic infections (diffuse abscesses, osteomyelitis, septic arthritis) [3,5,6] . Catheter infection may present with local and / or systemic symptoms.

Local infection findings: Inflammation at the site of catheter entry is one of the most common signs of infection. Redness, heat increase, pain, and exudate are encountered around the catheter exit site. Phlebitis develops in up to 30% of patients with a peripheral venous catheter, but catheter-related infection occurs in up to 10% of cases [3,6] . In tunneled, long-term catheters, such as Hickman-Broviac catheters, exit site infection can spread through the catheter (over an area greater than 2 cm), causing cellulite [3,4] . Inflammation, fluctuation and cellulitis around the implanted port, and sometimes necrosis in the skin covering the port [1,3-5] .

Systemic findings: Fever, chills, tremor and bacteremia may lead to septic shock. Hypotension, hyperventilation, respiratory failure, abdominal pain, vomiting, diarrhea, confusion, convulsions may occur in patients going into shock [3,5-7] .

Peripheral or central septic thrombophlebitis may be accompanied by chills, chills, fever and shock; this is especially the case in gram-negative bacilli infections [3,5,6] . Conditions suggesting catheter-related sepsis are summarized in Table 2 [1-6,8] .

Shock occurs more frequently when the infusate is contaminated and has a fulminant course; however, these findings are not common in catheter-related infections [3,5,6] .

Embolic events or other signs of metastatic infection may occur (such as Candida endophthalmitis) [5,6,9] .

Laboratory Diagnosis

Clinical findings (evaluation of local and systemic findings in patients with catheters) and microbiological studies are two important aspects of the definition.

In some cases, radiological investigations are also applied (investigating thrombotic / embolic events: radiographs, ultrasonography (USG), computed tomography (CT), radiological evaluation after venous catheter administration or venous Doppler USG study showing fibrin formation or intra-lumen narrowing. may contribute to the diagnosis of catheter infection [9-11] .

Gram Staining

Gram and acridine staining from catheter discharge is helpful in rapid diagnosis, but its sensitivity is low compared to quantitative methods [12,13] .

Catheter Outlet Culture

Swab culture from the catheter outlet site predicts catheter-related infection by 66%; the absence of reproduction in the culture indicates that the catheter culture would be 97% negative [6,11,14] .

Catheter Culture

The catheter can be semi-quantitative (Maki method) or quantitative (sonication method) culture; they are more specific than qualitative cultures. The predictive value of quantitative and semi-quantitative cultures varies according to the type, localization, type of culture and source of colonization. In the semi-quantitative culture, the tip of the catheter is rolled onto the media surface and ≥15 colony bacteria growth is significant in the culture after a 24-48 hour incubation period [1,4,6,11,15,16] . To assess the bacteria in the catheter lumen, 1 mL of tryptic line broth is sonicated in the catheter or sonicated in the broth, followed by seeding after 100 consecutive dilutions. At the end of 48-72 hours of incubation at 35 ° C, 10 2 or more colonies are indicative of catheter infection. With this method, it is possible to reach not only microorganisms that are on the outer surface of the catheter, but also lumens and biofilm adherent microorganisms, and sensitivity and specificity have been found to be generally 80-90% in the studies and it is a sensitive method especially for catheters that remain in place for more than 1 week. 20% more sensitive than the method [1,5,7,14,17] . Bacterial growth 18-24 hours after the catheter tip is simply thrown into a liquid medium does not give specific results due to the possibility of contamination during removal and this seeding method is not preferred [1,14,15] .

If the catheter is not removed, Gram staining or quantitative culture of the catheter outlet smear together with catheter hub cultures may help to diagnose.

Another method that does not require catheter removal is to take the sample through the kat brushing içinden technique, allowing the biofilm in the catheter lumen and the microorganisms attached to the thrombus to the end to be grown and cultured in culture; however, this method has a 6% risk of transient bacteremia [5,18] .

Blood Cultures

At least two sets of blood cultures should be taken from patients with suspected catheter-related infections. In case of suspected catheter infection, quantitative culture is performed from the blood taken from a peripheral vein with the relevant catheter lumen or the reproduction time of blood cultures taken from automated systems is monitored. Skin antisepsis should be considered when taking blood culture, contamination can lead to misleading results. The positive predictive value of catheter and peripheral venous blood culture for catheter infection was 63% and 73%, respectively; negative predictive value is 99% and 98%, respectively [19] .

If the number of colonies detected in the culture of catheter blood is 5-10 times higher than the culture of peripheral venous blood, the diagnosis of catheter infection is made. In automated systems that detect reproduction by signal, catheter blood reproduction is 2 hours before the peripheral vein blood sample, indicating catheter infection; sensitivity and specificity of this method have been reported as 91% and 94%, [1,4,7,8,11,14,20] . Simultaneous blood culture from catheter and peripheral blood allows diagnosis and selection of appropriate treatment in Hickman Broviac or subcutaneous central venous catheters without catheter removal. A single positive blood culture is important for the diagnosis of candidemia [2] .

Bacteremia due to infusion fluid is rare. The growth of the same microorganism in infusion fluid and blood culture is diagnostic. Clinical manifestations immediately after infusion suggest bacteremia due to infusion fluid.

PROTECTION

Catheter-related precautions and catheter-related infections can significantly reduce catheter-related infections and bacteremia. Risk factors associated with catheter infections should be considered at the point of prevention ( Table 3 ) [4,6,21] .

Catheter Indication

For catheter insertion, it should be indicated first.

1. Inadequate venous access,

2. Requires long-term total parenteral nutrition (TPB) or chemotherapy,

3. Venous sclerosing agent application,

4. Indication of catheter insertion in emergency situations.

Unnecessary catheter application should be avoided and the catheter removed when the indication ends [4] .

Infusion Treatment Team

Written rules on infusion therapy and catheter use should be established and updated regularly. A team of pharmacologists, infectious diseases and clinical microbiologists, nurses and physicians performing intravenous (IV) interventions may be involved in the preparation of guidelines and guidelines. Special IV treatment teams can be established for IV interventions. The formation of experienced infusion treatment teams can reduce the catheter-related infection rate by 8-10 times. Especially in centers with a high incidence of catheter infections, it is more economical to appoint an infusion treatment team. In the absence of a team to monitor the event at all levels, relevant health personnel should be trained at regular intervals [4,22,23] .

Selection of Catheter Type and Place of Application

Catheter type and site are effective on the risk of infection development ( Table 3 ). For example, the rate of infection in central venous catheters is higher than in peripheral venous catheters; in adults, the venous catheter to the lower extremity (femoral) is more risky than the upper extremity (subclavian <jugular) [21] . In the upper extremity, the risk of infection in the upper hand veins is lower than in the upper arm and elbow. On children's hands and feet or scalp may be preferred. Infection in peripheral venous catheters is lower than central venous catheters. For central venous catheter insertion, the risk of infection in the subclavian vein is lower than in the jugular and femoral vein. If there is no contraindication, the subclavian vein should be used instead of the jugular and femoral vein [24] . It should be noted that down cut-down dı increases the risk of infection. Multi-lumen catheters should not be used unless specific indications, as they are more infected. Multi-lumen catheters are useful when different fluids such as long-term high-dose chemotherapy, blood products, total parenteral nutrition (TPB) are required. If a multi-lumen catheter is used, a lumen should be reserved for hyperalimentation [24] . Multi-lumen and multi-purpose catheters have a high risk of developing infections, so these types should be avoided as much as possible [4,22,23] .

The catheter should be chosen with the lowest and most economical risk of infection according to the treatment considered, and the catheter should be removed immediately after the indication is eliminated. The construction material is also important in the selection of the catheter. Polyvinyl chloride and polyethylene catheters have a higher risk of thrombosis and infection than teflon, silicone and steel titanium catheters [4,23] .

Many microorganisms (staphylococci, candida) show more adhesion than polyvinyl chloride catheters, polyurethane and teflon catheters. There is a greater risk of mechanical complications (obstruction, thrombosis, leakage, displacement) with polyvinyl chloride catheters. The risk of infection in steel needle use is similar to that of Teflon catheters. However, irritant IV fluids used from steel needles can escape into subcutaneous tissues and cause complications. Steel needles should not be used in cases where such fluids should be given [4] .

Dacron cuff in non-implanted catheters causes inflammatory reaction and fibrosis. Dacron cuff does not prevent the development of infection [22] .

Central venous catheter (SVC) or peripherally inserted SVC (PSVC) should be used if treatment longer than 30 days is required in patients older than 4 years. Tunneled or implanted catheters should be used when longer treatment is required [24] .

Catheter Installation

Maximum barrier and asepsis precautions should be taken during catheter insertion. Particular attention should be paid to the rules of asepsis (hand washing, long-sleeved sterile shirt, mask, cap, large sterile drape, sterile gloves ...), especially when inserting a central venous catheter [6,23,25,26] . Using local antimicrobials (mupirocin, chlorhexidine), washing the catheter lumen with antibiotics, using catheters with antiseptics or antibiotics, and tunneling are among these measures [2,4-6,22,23,27-29] .

In case of insertion or removal of catheter, daily examination of catheter insertion area, before and after dressing, hands should be washed. Water, soap, antiseptic soaps or alcohol-based gels can be used in hand washing [30,31] . Sterile gloves should be worn after handwashing during catheter insertion / removal [4,22] .

The most important point during catheter insertion is skin cleaning; 2% chlorhexidine, 10% povidone iodine and 70% alcohol are more effective for this purpose [25] . Povidone iodine may be used in patients with chlorhexidine allergy. If povidone iodine is used, it should be applied for 3 minutes and iodine should be allowed to dry. The use of post-iodine alcohol in povidone prevents irritation. Organic solvents such as acetone should not be applied to the skin before catheter insertion. In addition, routine administration of antibiotic pomades instead of catheter access is not recommended [24] .

The bristles at the catheter inlet can be cleaned, but should not be shaved. It is useful for patients to bathe with disinfectant before catheter insertion. After skin cleansing, the entry site should not be palpated (palpable if working in a sterile area).

Catheter Care

Catheter infection rates (infection per 1,000 catheter days) are monitored by regular surveillance. In this context, variables such as catheter wearer (s), catheter insertion time, catheter insertion site, catheter type, treatment administered, and catheter removal time should be processed and evaluated on surveillance forms. Complaints and symptoms related to catheter infections should be evaluated daily and necessary diagnosis and treatment procedures should be performed in case of suspected catheter infection [4,6,22,23,29] . An intravenous catheter should be applied and the patient should be examined daily. Wound dressing should be performed after catheter insertion. Porous adhesive dressings should be used instead of occlusive dressings. Good quality sterile gauze is used for dressing; In recent years, transparent, semi-permeable and polyurethane dressing has been increasing in practice [4,22] . The dressing of the peripheral catheters can be changed every 72 hours. It is reported that this period can be extended up to 7 days [31] . The dressing should be changed when the catheter is altered, removed, or when the dressing is contaminated, wetted, loses its sealing ability, and bleeding occurs [22,24,31] . Wash hands before and after dressing change. Sterile or clean gloves should be used when changing dressings [30].

Catheter Insertion Time and Replacement

Peripheral venous catheters should be replaced after 72-96 hours, and if the catheter is inserted in an emergency, it should be replaced within 48 hours [30] . The catheter can be left in place as long as there is no sign of inflammation in children and the catheter works. Artery catheters can be left in place for 6 days and pulmonary artery catheter for 5 days; suitable for longer periods in children. Leaving catheters in place longer than the specified periods increases the risk of infection. The total parenteral feeding catheter may remain in place for up to 30 days [4,22] . Routine replacement of central venous catheters has no role in preventing catheter infection.

The IV administration sets do not need to be replaced before 72 hours unless otherwise indicated. There was no difference in the risk of infection between the replacement of peripheral catheters at 72 hours and at 96 hours [30] . If blood, blood products, lipid solutions have been administered, IV administration sets should be changed at the end of the infusion or within 24 hours.

Catheter hubs and ports should be cleaned with alcohol, chlorhexidine or povidone iodine prior to drug administration [21] . Sterile syringes should be used in every attempt.

Washing Solutions and Anticoagulant Usage

In long-term catheters, there are various recommendations for washing the lumen with washing solutions and anticoagulants. The use of heparin for this purpose prevents the development of thrombophlebitis, but facilitates coagulase-negative staphylococcal growth in catheters. The use of EDTA reduces the risk of infection due to coagulase-negative staphylococci. In high-risk patients, washing with EDTA and minocycline may prevent recurrent catheter infection [4,22] . Low-dose warfarin prophylaxis is useful in preventing thrombosis in patients on long-term intravascular catheters [21] . Patients should be educated verbally and in writing about catheter care and hand washing.

Filters

Filters prevent the passage of contaminated liquids. It reduces the risk of phlebitis due to infusion. It prevents the passage of gram-negative microorganism endotoxins. However, fluids such as dextran, lipid, and mannitol can lead to clogging of the filters and reduce the efficacy of drugs, so the use of filters for infection control is not recommended routinely [30] .

Antibiotic Prophylaxis and Antibiotic Catheters

Although antibiotic pomades administered during and after catheter insertion may prevent the development of infection, they increase the risk of Candida colonization; mupirocin administration, for example, reduced internal jugular catheter colonization by 5-fold; but the same effect was not observed in peripheral vein and artery catheters; and the use of prophylactic mupirocin has led to selection of resistant strains. Antibiotic pomades are not recommended for catheter dressing applications at additional costs [6,22,23,27,29] . Systemic antibiotic prophylaxis is also not required. The use of prophylactic glycopeptides may cause selection of resistant microorganisms [21] .

Antibiotic (vancomycin / teicoplanin, minocycline + rifampin), antiseptic (chlorhexidine, chlorhexidine + silver sulfadiazine) coated catheters have been shown to reduce the risk of infection with antiseptic hub administration [23,28,29] .

The use of antimicrobial-containing catheters may lead to the development of resistance to the antibiotics used [32] . The duration of protection in antimicrobial catheters was reported to be 14 days. In this context, it is recommended to limit the use of such catheters in cases where infection rates and risk of sepsis are high. Antibiotic catheters should be used when short-term (<10 days) catheter insertion and at risk of catheter-associated bacteremia (total parenteral nutrition, immunodeficiency, intensive care stay) and if the catheter will remain for more than 4 days [24,30,31] .

Antibiotic lock prophylaxis is to wash the catheter lumen with antibiotic solutions and then release the antibiotic into the catheter lumen. Vancomycin and ciprofloxacin were used for this purpose. Routine use of vancomycin cannot be recommended since vancomycin may cause a risk of enterococcal resistant infections [30] .

Indications for Catheter Removal

In cases where catheter-related infection is considered but there is no redness, tenderness, purulent discharge at the catheter insertion site, the catheter should be removed and cultured from the tip. A new catheter is inserted from the same place via the guide wire. If culture is negative, the catheter is left in place, if culture positivity is present, the catheter should be removed and a new catheter inserted from a different area. Indications for catheter removal as a result of catheter infection are given in Table 4 and cases where they can be left in place are given in Table 5 [1,3-6,8-11] .

As a result; appropriate catheter and catheter placement, aseptic catheter placement, proper catheter care, replacement of the catheter if necessary, avoidance of antibiotic prophylaxis are the basic rules that must be followed in preventing catheter infections.

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Radiation and radioactive materials have become an indispensable part of today's modern society and industry. With its unique properties, radiation provides benefits in many areas, particularly in energy, industry and health. Some of these uses are: precision clock production, sterilization, DNA sequencing, determination of metal fatigue in aircraft and generation of large amounts of electrical energy. The range of application of radioactive materials is so extensive that modern life is unthinkable without these materials. We benefit from the benefits of this technology as well as the necessary safety during the production, use and storage of these materials. If safety precautions are not taken properly, radiation accidents will be inevitable.

General Preparation in Hospitals to Intervene in Radiation Accidents

Hospitals should regularly assess the risks in the environment they serve and have the necessary personnel and equipment available in accordance with the risk they determine. However, a minimum level of preparation is required in all hospitals. Since hospitals will need to cooperate with the fire brigade, the security forces and the relevant government agencies, it is beneficial to establish a certain level of relationship with these units. It should be kept in mind that decontamination can be completed at the scene to a great extent if the teams performing the first response to the accidents intervene as necessary (1,2).

A planned activity should be initiated when there is a notice that a radiation casualty will be brought to the hospital. The person answering the phone should try to get as much information as possible about:

- Number of wounded,

- The medical condition and the type of injury of each injured,

- whether the survivors were screened for radiation,

- Radiological status of survivor (irradiated?, Contaminated?),

- Material causing contamination,

- Estimated time of arrival.

If there is doubt about contamination, the victim should be considered contaminated until proven otherwise. If the hospital has a special entrance for this type of incident, the ambulance personnel will be warned. If the notification comes from someone other than the emergency response teams, the telephone number to be requested is called back to verify the event before alarming the radiation responding team and starting preparations.

If a hospital is to respond to persons exposed to irradiation or contamination, provision should be made for such a situation. First, a treatment area should be identified. This area should be known by everyone and all the services of the hospital should be easily accessible. The treatment unit should be equipped with facilities to treat life-threatening wounded. Generally, a part of the emergency department will be allocated as “radiation emergency area” (RAA). Some centers have separated the morgue section for this purpose. However, the environment is not suitable for patients and relatives, and the necessary equipment for intervention may not be available in this section. In addition, the media may make inaccurate inferences due to the location of the patients (1).

Ideally, the RAA should have a separate entrance from the emergency room. This prevents entry-exit of other patients. However, this is not an absolute requirement. Access to RAA should be limited to personnel who will intervene in patients. RAA should be considered as a contaminated area. Everyone entering this area should wear protective clothing as if intervening in a septic phenomenon. No one should leave the RAA without a full-body contamination scan. Since the whole body scan will take 10-15 minutes at a time, unnecessary entries and exits to this area should be prevented. Personnel should remain in this area until the intervention is completed (1,3,4).

A region other than RAA is designated as the buffer region. In this zone, there should be a cabinet with all kinds of special equipment that may be needed to intervene in the radiation accident. Entry and exit to this buffer zone is limited to a nurse or staff assigned to this area. This area is considered a potentially contaminated area. The nurse in the buffer zone communicates with other emergency services and transmits any other material that may be needed, such as mobile x-ray, fluid, device or medication, to the RAA. This nurse can also record patient procedures, contamination levels and decontamination procedures, if any. To prevent unnecessary contamination, this area should be closed to personnel and other human traffic (3,4).

If time remains, the RAA and buffer should be covered with floor protection material. For this purpose, waterproof thick plastic material or thick paper can be used. The material should be taped to the floor (Figure 1). Covering the floor is not mandatory, but makes it easier to clean later. Traditionally, RAA is coated with “yellow” and the buffer zone is “green”. Plastic garbage bags should not be used to cover the floor. They are slippery and can cause accidents. Similarly, sheets or other fabric materials are easily folded, making movement difficult. In addition, fabric material is a material that makes it difficult to decontamination and can lead to the transport of radioactive material to shoes in other areas (3,4).

Personnel who will intervene in the patient should be protected from the possibility of contamination. For this purpose, it is enough to wear a double surgical gown and gloves. The double coat is intended to be easily removed when the outer coat is contaminated. Over-dressing can make work difficult if ventilation is not sufficient. To protect the shoes from contamination, plastic shoe covers should be worn on the feet and taped on both the wrist and the middle section (Figures 2, 3).

Dosimeters should be given to each personnel entering RAA. This rule normally includes personnel such as nuclear medicine-radiology technicians and nuclear medicine-radiology physicians who wear dosimeters. The aim of the dosimeter is to measure the radiation dose to which personnel is exposed during the patient intervention. A thermoluminescent (TLD) dosimeter should be fitted to the innermost body. If desired, a ring TLD dosimeter is attached under the gloves. TLD serves to determine the official radiation dose received. A pen dosimeter to be attached to the outermost can read the dose the staff is exposed to at any time. However, pen dosimeters are sensitive to vibrations and impacts may not provide accurate information in determining the exact irradiation dose (1,4).

Personnel Required for First Response

In any case, appropriate and trained personnel are required for on-site intervention. Anyone in this team, which can be defined as a radiation emergency response team, should be familiar with the radiation emergency plans of the hospital and participate in the exercises. For some subgroups in this group (such as decontamination, triage and radiological monitoring teams), the frequency of administration may be increased. Changing personnel are also subjected to the same training to ensure compliance with the team. These trainings should include emergency medical technicians and personnel carrying the wounded from the scene to the hospital. This is because these personnel play important roles in the pre-warning of the hospital and the proper transport of radiation injured (2). The tasks and functions of the radiation emergency response team are presented in a table below (Table 1).

Let us examine in detail the functions of some of the personnel to be employed in the team.

Emergency nurses: Nurses play the most important role in the intervention of many emergency patients. They clean the wounds and make them ready for the intervention of the physician. Emergency nurses are responsible for taking samples from suspected contaminated areas and performing final decontamination. Depending on the size of the accident, 1 or 2 nurses should always be present in the RAA.

Emergency Medical Specialist: Emergency medical doctors are used to respond to casualties. The task of the emergency physician is to stabilize the patient medically. Decontamination is performed after the patient has stabilized. Emergency medical attention always has priority over radiation decontamination. The emergency physician will remain in the RAA until the patient has stabilized and the life-threatening has been eliminated.

Trauma surgeon: Surgery is sometimes necessary to stabilize the victim. This intervention is performed by the surgeon or trauma surgeon. Again, these surgical interventions are performed before decontamination. The trauma surgeon stays in RAA until he no longer needs it. If the trauma surgeon undertakes treatment, the emergency medical practitioner may leave this area.

Nuclear medicine technician or radiation technician: If the patient survives and stabilizes, the areas of contamination should be identified, if any. This is done by a nuclear medical technician or radiation technician (radiation safety officer). These personnel should wait in this area during the patient intervention. If contaminated areas are known when the patient arrives, the technician reminds the patient to intervene to change contaminated gloves and gowns after the intervention. In no event shall this technician prevent or delay the initial medical intervention of the patient.

Security personnel: The presence of security personnel is important for two reasons. The first is the patient's privacy. Only the name of the patient, the time of admission to the emergency department and the general condition can be explained. Any other information to be disclosed is a violation of patient rights. Second, if people potentially enter this area continuously, contamination will be very likely to spread. Security personnel control the entry and exit of this area to prevent the spread of contamination and leakage of unauthorized information.

Public relations: Most of the time, radioactive accidents do not attract much attention and media coverage, but sometimes it can happen in front of everyone. In this case, the hospital should appoint someone experienced in this area to contact the press.

Necessary Staff for Advanced Care and Treatment

Surgeon: A trauma surgeon is often needed as most trauma is accompanied by a certain degree of trauma. This staff member could be called early or later. Surgeons should be aware of contamination control as these personnel intervene in other complications of wounds, burns and trauma, and may be needed at any time during the intervention.

Radiation technician: If there is contamination, the duration of irradiation, the distance to the source, and the amount of shielding and activity, if any, should be known to determine the irradiation that will occur. Dosimeters are read and prepared for complications of radiation. If contamination is present, necessary analyzes should be performed to determine the isotope. If an isotope is identified, appropriate decontamination therapy may also be initiated.

Nuclear medicine and / or radiotherapy specialist: Both of these experts will benefit from the management of radiation accidents. Nuclear medicine specialists are experienced in dealing with internally administered radionuclides. They can apply treatment for internal contamination of different isotopes. Radiotherapy specialists are also experienced in patients exposed to high doses of external irradiation. Their knowledge and experience will be helpful in identifying early and late effects in patients exposed to high dose irradiation.

Oncology / hematology specialist: Radiation casualties are in the high risk group for cancer in the long term, but the oncology / hematology specialist will be useful for other reasons in the early period. The oncology / hematology specialist is experienced in the treatment of immunosuppressed patients. If leukopenia is evident, protective isolation may be required. Bone marrow transplantation may also be a treatment alternative in patients exposed to a dose close to the lethal dose.

Internal medicine specialist: Patients with serious injuries may need to be hospitalized for long periods of time. If surgery is not required, an internal specialist may be required to coordinate the overall treatment of the patient. Liquid electrolyte balance may be impaired in patients exposed to high doses of radiation. The patient may be lost if not treated properly. Infection and other complications due to long-term hospitalization may also require treatment.

Legal adviser: Radiation accidents can also have legal consequences. The hospital and personnel being prepared for this situation will undoubtedly allow for the proper preparation of the necessary materials and documentation.

Emergency Response Team (ADME) Preparation

Protective clothing: Protective clothing is intended to protect bare skin and personnel clothing from contamination. Team members should wear surgical clothing (gowns, masks, caps, eye protection and gloves). Waterproof shoe covers or shoe covers are used. All open areas and floor sections are taped. The end of the tapes is folded for easy removal when necessary. Gloves should be worn in double coats. The first layer of gloves is taped under the surgical gown arm. The second coat must be easily removed and replaced if necessary. The dosimeter to be distributed to each team member is attached around the neck area outside the surgical gown. If available, another type of dosimeter is worn under a surgical gown. Each team member who uses fluids for decontamination should also use a waterproof outer apron.

These protective suits effectively inhibit alpha and some beta particles, but are not useful for gamma rays. Bulletproof aprons that cannot stop most gamma rays are not recommended, as they create a false sense of security.

Preparing the treatment area for contamination control: The treatment room should be prepared , if possible, near the external entrance. Visitors and patients are removed from this area. Equipment that will not be used in emergency response to the victim is either removed from this area or covered. Several large plastic trash cans will be needed.

The treatment table is covered with several layers of waterproof disposable drapes. Plastic waste bags should be available in all sizes.

The devices used in radiation monitoring are checked for batteries and operation. Again, background activity is determined and recorded before patients arrive. The team is prepared to receive the patient by the ambulance.

Covering the floor: Brown wrapping paper is laid out from the ambulance area to the treatment room. Regardless of the material used to cover the floor, it should be fixed with tape on the ground. This path is then separated by safety ropes to prevent unauthorized access. The decontamination chamber and treatment area are also covered with the same material if time is left. This will facilitate subsequent cleaning. The threshold of the decontamination chamber is clearly marked with a thick band to define the boundary of the contaminated and clean zone.

Control of ventilation: It is preferred that the ventilation of the separated section is a separate ventilation from other areas. Or the passage of air in this area to other sections without filtering should be prevented. Contamination is very unlikely to be suspended in the air and into the ventilation system.

Patient Admission

Pre-admission: The most often overlooked issue in hospital preparation is pre-admission to the hospital with the first intervention team. The emergency department team is contacted about patient and injury patterns. The emergency personnel are familiar with respiration, pulse, blood pressure, skin color, pupillary reflex, and other signs and symptoms. However, the average staff does not know enough about the evaluation of radiation data. A description by the on-site radiation technician of 10,000 10,000 hands and 2,000 DPM contamination of the scalp abilir can create hesitation and fear for staff interfering with the patient. If the hospital is close to the facility that uses radioactive material, it is imperative that both the emergency responders and hospital staff understand the radiation language. Drills are an important part of the preparation and should be carried out at least once a year with the participation of the facility using the radiation, the emergency response team and the emergency service team.

As in any accident involving dangerous substances, it would be very useful to know the material causing contamination, the amount of irradiation and the affected body areas. If the accident occurred during the transport of radioactive material, the contents and the amount of activity shall be clearly written on the package.

A common pre-agreed language should be used in pre-acceptance communication. It is not easy to determine the radiation in rad or gray at the scene. Instead, it is easier to express contamination in terms of DPM (counting per minute) or CPM (counts per minute). This data should be provided by persons who are knowledgeable. Information should be provided not only on contamination, but also on the type of the boiler, the material involved and the affected areas, if known.

Clean transfer between teams: When the patient arrives at the hospital, the ambulance / helicopter and personnel should be considered as contaminated. The patient should not be directly admitted to the hospital by a potentially contaminated ambulance gurney or staff. In this case, contamination can spread rapidly throughout the hospital by other unaware staff.

The easiest way to overcome this problem is to perform clean transfers between teams. To perform such a transfer, a potentially contaminated area around the incoming vehicle is determined. The ambulance will approach this area. Ambulance personnel should not leave this area. Ambulance personnel are met by hospital personnel at the border of this region. The ambulance and hospital gurney are brought side by side to this border and the patient is taken to a clean stretcher and transports to the hospital. A similar procedure can be applied for helicopters. The inside of the helicopter runway ring is designated as a contaminated area and transfer is made in this line.

Thanks to the clean transfer, the patient can be taken to the emergency room or the operating room without suspicion of contamination.

Releasing the emergency response team: The team members bringing the patient are checked for contamination by an experienced technician. Until this process occurs, team members are not allowed to eat, smoke or drink liquids. If there is contamination, it will be inevitable that external contamination, which can be treated more easily in this way, will turn into internal contamination, which is more difficult to control.

The whole body scan of the team and the control of the vehicle interior are performed according to the routine procedure. If no contamination is detected or contamination is removed, the team is allowed to leave.

Result

Radiation and radioactive materials have become an indispensable part of today's modern society and industry. So we have to learn to live with them. Increasing use of radiation and radioactive materials increases the risk of accidents with them.

Intervention to radiation accidents should be a multidisciplinary approach. It is of utmost importance to bring the survivor from the place where the incident took place to the health institution, and to train personnel who are conscious about radiation and radioactivity in all the processes up to the discharge of all kinds of interventions there. In addition, health institutions where the first interventions of such victims should be prepared should be made ready for radiation accidents. Consequently, the establishment of a team (ADME) to intervene in possible radiation accidents in each health facility and providing continuous in-service training to this team will also minimize the risk of injury to an accident victim and other personnel in charge.

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TRAVEL VACCINES


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Passengers traveling abroad face many risks of infectious diseases that are not seen in their home countries. Passengers should be informed about the risks of diseases and preventive measures in the countries to be visited and necessary vaccinations should be given.

It is decided by the evaluation of the characteristics of the person and the journey which vaccines should be given before the trip. In other words, the vaccination schedule required before the trip is individual. The characteristics considered in this risk assessment are:
Personal features:

Age (some vaccines may not be available in children and the elderly or their efficacy and side effects may be different)
Health status (Some chronic diseases, such as diabetes, may cause more susceptibility to certain diseases, some vaccines may not be available in some diseases)
Pregnancy and lactation (Some vaccines may not be available)
Immune system failure (Some vaccines should not be given)
Allergy history
Vaccination history

Features:

Country of destination (Some diseases may be more frequent in some countries)
Time of journey (Some diseases may occur at certain times of the year. For example, during the rainy period)
Duration (Increased duration increases risk)
Accommodation (Rural disease risks may be higher, camping site risk is higher than hotel)
Travel activities (activities such as working in rural areas, hiking can increase the risk)

Following vaccination, a period of time must elapse for the protection to begin. This time varies depending on the type of vaccine, the number of vaccination doses required, the vaccination history. Passengers should contact Travel Health Centers at least 4-6 weeks before travel to ensure adequate immune response and to complete the necessary vaccination schedule. Ministry of Health, Turkey General Directorate of Border and Coastal Health Travel Health depends on a free vaccines made in Central and preventive medications. Travel Health Centers can be applied by making an appointment at the addresses of our centers.

It should be borne in mind that no vaccine can provide 100% protection and that general infection prevention measures should be followed, even if the vaccine is administered.
Routine Vaccines

In some countries of the world, diseases such as tetanus, diphtheria and measles are endemic. For this reason, it is very important that the passengers receive their vaccinations in accordance with the national calendar. Many childhood vaccines require additional doses of vaccine throughout life to maintain effective protection. If there are any missing vaccines according to the routine vaccination schedule in the pre-voyage assessment, people who have never been vaccinated should complete the first vaccination series. Some of the vaccines included in the routine vaccination program include:

Tetanus-Diphtheria (Td)
Measles-Rubella-Mumps (NCC)
Polio

Travel Vaccines

Recommended for each passenger based on journey risk assessment.

Yellow Fever (mandatory)
Meningococcus (mandatory)
Typhoid

Cholera
Hepatitis A
Rabies

Japanese Encephalitis
Tick-borne encephalitis




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HOW TO MAKE A PATIENT BED


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Generally, patients spend most of the day in bed. Therefore, the clean and comfortable bed of the patient will affect the patient physically and psychologically. Patient bed should be tidy and clean. The following describes in detail how a patient bed should be made.

Making the bed: The bed can be made by one person or with the help of two people. Care should be taken to observe the body mechanics while making the patient bed. When making the patient bed, care should be taken to use easy-to-clean and durable materials.

Important Note: During the construction of the Patient Bed, platinum recommends opening the windows to ventilate the bedroom. When the room is ventilated, the patient bed is ventilated.

Materials to be used in Patient Bed Construction;
- Gloves
- Patient bed protective cover (Alez)
- Bed linen
- Linoleum
- Intermediate sheets
- Linens
- Blanket
- Pillow
- Pillowcase
- Pike

How to make an empty hospital bed?
- Hands are washed, dried, gloves are worn. This prevents contamination.
- The window of the room is opened and the room is ventilated. At the same time, the patient bed is ventilated during the construction of the bed.
- Clean bedding sets (bed top, bottom cover), bed sheet, linen sheet, intermediate sheet, blanket, bed linen, pillowcases and pique folded are kept next to the patient bed. The purpose of this is to provide convenience in bed construction and to prevent waste of time
- Borders of the patient bed are lowered for ease of application.
- To prevent contamination of the bed, the bed protector is laid on the mattress (mattress) by passing to the close side of the bed.
- For ease of application, Bed linen is taken, folded in quadruple width, folded on the bedside. The first floor is spread out on the opposite side of the bed, and the other floor is spreading towards the foot of the bed.
- In order to prevent the formation of bed sores and to ensure that the bed is tidy, the platinum bed is recommended to be tightened under the bed by making triangular corners.
- If necessary, the linoleum is placed in the middle of the bed (ready-made diapers can also be used).
- Intermediate sheets are laid on the intermediate linoleum (instead of the intermediate sheets, the bed linen can be doubled.) The linoleum and the linen on both sides of the bed are placed together under the tension. Objectives; To prevent contamination of beds and sets and prevent the formation of bed sores (decubitus)
- Blanket is put on the bed linen and laid on the sheets. The parts of the bed hanging from the sides are folded inward. Purpose of construction Prevent contamination of the blanket.
- Pike is placed on the bed linen, the edges are corrected curled under the bed with the foot bed linen. Objectives; To ensure regular beds
- Pillow cover is put on the pillow and placed on the bedside. It is made to create the bed arrangement and ensure the use of the pillow of the patient.
- Remove gloves, wash hands and dry. The purpose is to prevent contamination.

ATTENTION: When collecting dirty patient bed sets, tossing them and collecting them nicely, the microorganisms in the teams, skin rashes and the air into the environment. Therefore; while collecting bedding sets should be collected without hurling and their volumes should be reduced and thrown into the dirty cart.

Making the patient bed with the patient:
It is a system applied to change bed sets without removing bed dependent patients from patient bed. Apart from the materials used in the construction of an empty patient bed, it will help in making the patient bed; If necessary, the bolt or duck should be kept with you. Cleaning cloths also need to be kept in accordance with the need.
- The procedure for informing the patient is explained and permission is requested.
- During the construction of the patient bed, the patient's participation is ensured and communication is supported.
- Wash hands, dry and wear gloves to prevent contamination.
- To facilitate the application, bed linen is brought to the patient bed with a trolley or basket. Patient bed sets are taken according to the order of use.
- The window of the room is opened to allow ventilation of the room. Note that the room's door must be closed when the room window is opened.
- In order to facilitate the application again, tools such as whatnot, chairs and calling etc. are removed from the patient beds.
- To ensure the privacy of the patient, external images are prevented.
- The patient is asked if there is a need for discharge, if any, it is removed and cleaned first.
- If the patient needs to evacuate, the healthiest method is to clothe the patient. Sliders etc. inventory increases the risk of infection.
- After cleaning the patient's bottom is removed with gloves.
- The first thing to do to protect the privacy of the patient and prevent it from chilling is to cover the patient with diving.
- The collection of dirty bedding starts by pulling the blanket with bed linen under the pike to the foot of the patient.
- Blanket is removed from the bed linen and then put on the chair. To reduce the risk of infection in the linen, the dirty side is folded in and placed in the dirty bag.
- Starting from the remote area, the lower patient bed sets are loosened.
- The patient's pillow is removed and the sheath is removed and flipped again and thrown into the dirty bag. Pillows are put on the chair.
- The bearing border on the far side is removed. The patient is placed on the bed in the lateral position with the patient's back facing the nurse.
- Dirty bed linen is rolled or rolled up and pressed under the patient without disturbing the patient.
- Half of the clean bed linen is rolled or crimped and pressed against the patient.
- Linoleum and linen sheets are placed in the same way.
- Lift the bearing edge on the working side and move to the remote side. The bearing edge on the far side is lowered. The patient is turned laterally to the side where the clean bedding is placed.
- Dirty bed sets that we roll from under the patient are pulled and thrown into the dirty bag. Clean bed linen is pulled from the bottom of the patient towards the edge of the bed.
- The patient is placed in the supine position.
- All sides of the clean bedding are tightened and the corners are made triangular and compressed under the mattress.
- The corrected undercarriage must be taut and free of wrinkles. Relieve the patient. Prevent bed sores
- The blanket is laid over the patient with the head open.
- The blanket is placed inside the duvet with the corners of the blanket facing the corners of the duvet.
- Pike is covered on the bed linen with the patient's head open.
- Foot side is placed under the bed.
- Put a clean cover on the pillow.
- Etajer and calling bell are placed within the reach of the patient.
- Remove gloves, wash hands.
- Points to consider;
- Care is taken not to open the top while protecting the privacy of the patient.
- Screen or curtain is drawn around the patient bed.
- Room temperature is taken care of to prevent the patient from getting cold.
- The application is made by contacting the patient.

CHARACTERISTICS AND ARRANGEMENT OF THE PATIENT BEDROOM
In order to make patients feel comfortable and safe during the treatment process, patient beds should meet the requirements under appropriate conditions. In order for the patient to undergo a more efficient care process, it is important to arrange the bed in conditions that will increase the treatment efficiency. Patient bed models produced for patients may vary depending on the patient. Patient beds should be organized and organized. The patient must be electric and motorized to use the patient bed if necessary. Thus, the patient bed should be able to use the bed itself. While choosing from patient bed models, it is useful to choose an electric patient bed model.
There may be a single patient bed (single bed) or companion bed in the patient room.

How should the patient bed room be?
The Patient Bed should be designed to meet the physical and psychological needs of the patient and to allow the caregiver to perform the care of the patient comfortably.
The room where the patient bed will be placed should be at least nine square meters. Assuming that the companion sleeps in the same room, it should be at least fourteen square meters.
There should be a space-saving built-in cupboard in the patient room where the patient can put his / her special belongings.
The room should be designed so that the patient can be intervened at any time.
There should be at least one meter intervention area on the right, left and bedside of the patient bed. There should be at least thirty cm air passage at the head.
Ventilation and lighting of the room where the patient bed will be placed should be sufficient.
The wall color of the room where the patient bed will be placed should be selected from natural, soft and pastel colors in a way that will comfort the patient.
Patient bed rooms should be able to receive direct and sufficient amount of daylight, smooth and easy to clean walls and floors and be suitable for disinfection.
The patient bed wheels are rubber and the platinum bed recommends that all four have brakes. It is difficult to keep patient beds with four wheels without brakes, if there is play on the floor. In order to secure the patient bed without any problems, floor coverings should be preferred from durable, non-slippery and noise-preventing materials.
The patient bed should be easy to clean, durable and easy to move when necessary.
When arranging patient beds and room;
Regulation of physical environment
Ventilation of the room and patient bed
elucidation
good regulation of temperature and humidity should be considered.
1-) Regulation of Physical Environment
It is effective on the physical environment, human health and behavior. The regulation of the physical environment makes the patient feel safe, protected from accidents and infections, and the treatment process is comfortable.
The order of the physical environment should be soothing to the individual. The regularity of the physical environment also relieves the patient psychologically.

In the Patient Room;
There should be patient beds that are useful for the patient and can meet the physical needs of the patient.
Patient beds should be placed near the window according to the characteristics of the room.
The bedside table must have a drawer inventory or a patient dining table.
There should be a chair next to the patient bed so that the patient can sit as needed.
There may be a telephone and television in the patient's room for a better time. The platinum bed recommends that the patient bed be positioned so as not to interfere with watching television.

2-) Ventilation of Patient Bed Room:
The air of the closed room where the patient bed is located; It is polluted by the microorganisms that are scattered to the environment by the breath, sweat, smell, heat, humidity of the room. The oxygen of the air decreases and the carbon dioxide increases. In this case, the room should be ventilated.
In the environment of the patient bed; clean air, humidity and heat should be sufficient. The replacement of the ambient air with dirt and bacteria-free air is called ventilation. Ventilation is done in two ways. These; natural ventilation and artificial ventilation.

Natural ventilation of the Patient Bed Room: Before the ventilation process is performed, the procedure and its cause are explained to the patient. The patient should be protected from airflow and dressed according to room temperature. Doors and windows are ventilation by opening each other.

Artificial ventilation of the Patient Bed Room: It is provided by the use of ventilation systems. Special means are used in this type of ventilation. For example; air conditioners and ventilators can be used for this purpose. The patient is covered over the air conditioner or ventilator to protect it from the air flow while it is operating.
Ventilation also recommends that the platinum mattress be at least twice a day without crashing in the morning and evening.
The short stay in patient visits is an element preventing the room from being airless. The platinum bed recommends that the patient visit one at a time if possible and do not stay inside for long.

Patient Bed Room Things to consider for the prevention of bad odors:
Frequent replacement and keeping of patient bed sets is recommended, and platinum bed sets are recommended to be cleaned in a dry cleaner.
Keeping the materials used by the patient such as cups, spoons and forks in a clean and closed place
Giving importance to patient and patient bed hygiene
Cleaning the patient rooms with suitable materials
No smelling food (eg pickles, etc.) being introduced into patient rooms
Removal of residual nutrients from the room after meals
If the patient has changed dressing wastes should not be left in the room
If there is a flower vase in the room, its water should be changed every day.
There are ducks, sliders and so on. the bucket in the room is closed and the garbage bag is changed every day

3-) Illumination of Patient Bed Room: The desired level of illumination of patient bed rooms ensures that the patient is in a comfortable environment and that the procedures to be carried out are easy to carry out. Lighting is divided into natural and artificial lighting.

Patient Bed Room Natural lighting: The lighting obtained by using the sun. The sun plays an important role in health. The sun gives people joy, plays a role in the development of children; Gives natural heat and illuminates indoor areas and relaxes the person. The patient recommends the use of platinum bed windows and curtains to make the most of the sun in bed rooms.

Patient Bed Room Artificial lighting: Artificial lighting is the electricity provided by the lighting. In electrical lighting, it should be ensured that the light is not very bright and does not come directly into the eye. The general illumination of the environment should be sufficient. Adequate light in artificial lighting is important in creating a suitable environment for nursing care and treatment and ensuring safety. At night, the platinum bed recommends using light-emitting lamps that distribute light to the wall or ceiling so that patients are not disturbed by excessive light and are safe.

4-) Heat and Humidity in Patient Bed Room: Platinum bed is recommended to be 18-22 0C in patient bed rooms. This heat should be maintained in summer and winter. In summer, this heat is provided by opening the room door, window or by using cooling devices (air conditioning, ventilator, etc.). In winter it is maintained with central heating and air conditioning. In some applications, room temperature may need to be increased (such as a bed bath) .The cilia in the respiratory tract mucosa must be moistened with mucus to function. Drying in the mucosa increases susceptibility to infections. It is therefore important to moisten the inhaled environment. The humidity of the patient room air should be between 30-60%. If necessary, the humidity of the air breathing can be increased by special devices.

5-) Noise in Patient Bed Room: Noise is an important source of stress. Patients need a quiet environment in the hospital. Stimuli that may cause noise should be minimized in order not to disturb patients. 9 In the researches, it was found that the types of noise that disturbed the patients were the voice of personnel speeches, footsteps, patient shouts, telephone bell, food, dressing carts and elevator doors.

Some of the measures to be taken to prevent noise;
Making warnings that should not be spoken loudly,
Ensuring that the sound of the call systems is reduced in a way that does not interfere with communication,
To ensure that the wheels of moving vehicles are covered with rubber,
Choosing materials that do not transmit noise in material selection,
Appropriate warnings when there is noise,
Wearing silent shoes or slippers,
MATERIALS NEEDED IN THE PATIENT BEDROOM
The patient bed room should be designed and arranged to meet the needs of the patient. In the patient's room, patient bed, patient bed (mattress) patient bed sets (blankets, linens, pillows, etc.) chairs, oxygen system, if necessary, patient dining table is useful.

1- Patient Bed: According to the needs of patients, at least the head and foot tip should be raised and lowered. Controlled patient cots should be preferred and the control should allow both the patient's use and the caregiver's use. The feet are wheeled and should be able to move to the bedstead and when it is desired to be fixed, platinum bed recommends that all wheels should be braked as opposed to normal bedsteads. The patient bed should have a guardrail. Patient bed; at least the head and foot part of the shield, wheel, designed for patients with side railings are called beds.

2- Patient Bed (mattress): Patient bed to be used in the patient bed must be suitable for long-term bed. Bed models that minimize the formation of pressure sores should be preferred. For long-term use, the platinum bed 23 recommends the use of a mattress with a dance hardness, and an air bed to prevent wound formation in patients hospitalized for more than 10 hours per day.

3- Pillow: The pillow can be of various size and thickness. It is made of cotton, feather, fiber, sponge pieces and wool. Although useful and comfortable, wool pillow is not preferred because it is difficult to clean in hospital 10 conditions. The purposes of the pillow are; placing them under the head to sleep, positioning or supporting the patient, relieving the breathing of asthmatic patients and raising the extremities high. Viscoelastic pillows can be preferred for ease and comfort.


4- Pillow cases: The pillow case is used to prevent the pillow from getting dirty. It is made of cotton fabric or calico. The sheath must be slightly larger than the pillow to fit it comfortably.


5- Intermediate tarp: Intermediate tarp is used to prevent contamination of the patient bed. An average length of 70-80 cm and 60-70 cm width of linoleum, 40-50 cm wide fabric is added to the bottom of the mattress to compress. Disposable spacers are preferred. Linen sheets that cover the bed completely can be used in units where patient beds are frequently contaminated, such as emergency services, children's services and intensive care. Bed linen in contact with the bed and mattress protectors made of cotton material in contact with the patient are used.


6- Intermediate sheet: Intermediate sheet is used to cover the intermediate sheet. It is usually made two meters wide and one meter tall. If there is no intermediate sheet, the bottom sheet can be folded and used for the same purpose. Today, ready-made diapers are also used instead of intermediate tarp and intermediate sheet.

7- Bed linen: Bed linen is made of linen, cotton fabric or calico. The width and length of the bed sheet (mattress) can enter under the size. Today, sheets and corners with rubber edges are also used.

8- Duvet Cover: Duvet cover is made of cotton or calico fabric. It is used by passing a blanket. It should be large enough to accommodate blankets.

9- Pique: Pique is made of light, washable and cotton fabric. It is used with or as a single bed linen.

10- Blanket: Blanket is made of synthetic and wool blend. It is preferably used by passing through the linen. Can be used as a single. The light weight is preferred.

11- Dining table: Dining table, height adjustable, wheeled, easy movement of the bed on the table makes it easy to eat.

12- Chair: Chairs that the patient or companion can sit should be durable and comfortable. Seats should be preferred if possible. It should be preferred that it is easily cleaned and covered with microorganism free material.


13- Etajer: Etajer is a small cupboard with drawers where the patient can put his / her daily use goods such as glasses, water and napkins. patient bed


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