Natural Vitality Natural Calm Drink - 16 Oz. Anti-Stress Drink, Orange Flavored Drink, Water-Soluble. Magnesium Supplement

Natural Vitality Natural Calm Drink - 16 Oz. Anti-Stress Drink, Orange Flavored Drink, Water-Soluble. Magnesium Supplement

The influence of the drug Magne B6 on the parameters of stress and cognitive function with high psycho-emotional stress

Introduction
The stress state of the body, in general, corresponds to an imbalance between external conditions and the body's ability to respond adequately to them. Systematic dissatisfaction with the results of social activities, restraint of emotional manifestations, due to social norms of behavior, often lead to the fact that modern people often experience a lack of peace of mind, emotional balance, along with the gradual loss of efficiency in work and the occurrence of chronic diseases.
The analysis of stressful conditions is one of the actual directions of research of unfavorable functional states of a modern person. Evaluation and enhancement of the adaptive capacity of the organism is considered as one of the important criteria for health. The higher the adaptive capacity of the organism, the lower the risk of the disease, since the protection against the disease is more reliable. Any kind of stress can be considered as a source of “trouble in work”, given its negative effect on the results of activities and the development of personal disadaptation and mental health problems [1]. The procedural-cognitive paradigm understands stress as the process of actualizing the repertoire of internal means of overcoming difficulties. The basic stress models include the two-factor model of “demand and control” [2] and the “hormonal model” [3].
In particular, stress during intensive training can be viewed as the result of an imbalance between the requirements of the learning environment and human resources, including a subjective assessment. The curriculum of students of the 3rd year of medical schools is characterized by information overload, especially during the exam session. High emotional and intellectual tension during the pre-examination and examination period can be considered as an adequate model of occupational stress for able-bodied people of young age and to apply methods for evaluating occupational stress among students. In this paper, we investigated the effect of magnesium in synergistic combination with pyridoxine on students' ability to adapt under conditions of increased stress. To study the anti-stress activity, the drug Magne B6 produced by the French company Sanofi-aventis was used.

Materials and methods
A sample of students. 89 third-year IvGMA students took part in the study. In the selection process, the volunteers were divided into 2 groups: the studied (first) group of 58 people and the control (second) group of 31 people. Students in the first group received Magne B6 therapy 2 tablets 3 times a day (daily dose of magnesium - 288 mg per pure magnesium, pyridoxine - 30 mg) for 2 weeks, then 2 tablets 2 times a day (daily dose magnesium - 192 mg, pyridoxine - 20 mg) for 6 weeks. Students in the second group (control) did not take any special drugs.
The average age of students in the study group was 20 years (19-25 years), the control group - 21 years (19-25 years). In the studied group, women accounted for 72% of the total number of the group of students surveyed, men - 28%; in the control group, a similar proportion of the sexes was observed (67% of women, 33% of men). The average body weight of students in both groups was 56.79 ± 3.46 kg for women and 72.8 ± 5.1 kg for men.
Exclusion criteria from the study were the presence of severe, acute and chronic somatic, mental diseases, taking any medications and dietary supplements. The study complied with the ethical standards of committees on biomedical ethics, developed in accordance with the Helsinki Declaration, amended in 2000 and the “Rules of Clinical Practice in the Russian Federation” (1993). All students gave written informed consent to participate in the study.
The examination report. Each participant in the study was examined according to the protocol twice. The first survey was conducted prior to the study and the second - at the end of the study (after 8 weeks). Statistically significant differences of students of the first and second groups were evaluated in dynamics - day "0", day "60". According to the protocol were evaluated and analyzed:
• Individual registration cards (IGC) containing medical and demographic (age, gender), anthropometric (height, body weight) characteristics, health data, information on social and labor status, attitude to smoking.
• The level of magnesium deficiency and pyridoxine, which were evaluated during testing using a structured questionnaire [4, 5].
• The level of stress exposure of students using the method of integrated diagnosis and correction of occupational stress IDICS, presented in the form of a structured questionnaire of 6 basic scales and formed in accordance with the hierarchical scheme of stress analysis [6]. A brief description of this technique is given in Table 1. According to the IDICS scale, manifestations of acute stress were: physiological discomfort, mental and emotional stress, difficulties in communication. For chronic stress, asthenia, sleep disorders, anxiety, depressive states, and aggression were also characteristic.
• Personal and behavioral deformities, assessed by the presence of signs of burnout syndrome (apathy, complete lack of interest in work and study), neurotic reactions, shocking or excessive isolation.
• The state of various types of memory, for which diagnostics of the general state of aural speech, visual and motor memory using neuropsychological diagnostic techniques using the DIAKOR program developed at the Faculty of Psychology of Moscow State University [1]. This made it possible to answer the question about the weakest links of the corresponding types of memory, such as the basic mental process, which influences the manifestation of other mental functions under the influence of occupational stress.

For statistical processing of the results of the study, methods of mathematical statistics were used, including the calculation of numerical characteristics of random variables, testing of statistical hypotheses using parametric and non-parametric criteria, correlation and analysis of variance. To test the statistical hypotheses about the difference in the mean values ​​of the signs, the method of visual comparison of 95% confidence intervals was also used. The estimation of the confidence intervals was made by the binomial distribution. To mark the boundaries of the 95% confidence interval of relative values, the “#” symbol was used, separating the upper and lower boundaries of the 95% confidence interval of the true mean value of a random variable. Comparison of predicted and observed frequencies of occurrence of characters was performed using the Chi-square test. For comparison of dependent variables, the most accurate Wilcoxon-Mann-Whitney T-test was used when conducting medical research (which, as is well known, is not limited to a certain form of distribution of a random variable). For statistical processing of the material used by the application "STATISTICA 6.0". Calculated confidence levels; P values ​​were considered significant
Results and discussion
There were no statistically significant differences in the age, gender, or body mass of the students in both groups (p> 0.05). Table 2 shows the analysis of the incidence of diseases in the students surveyed. Analysis of the frequency of occurrence of individual diseases recorded in students in the IGC, showed that the most common among students of both groups are diseases of the gastrointestinal tract, cardiovascular diseases. For all diseases, there were no statistically significant differences in the incidence of individual diseases between groups 1 and 2 (p> 0.05).
The homogeneity of the studied groups was also analyzed by means of a pair of correlation methods for Spearman. In both groups, on the day “0”, clear correlations were observed between the levels of magnesium deficiency and the parameters on the IDICS scale. Thus, correlations were found between the level of magnesium deficiency and conditions, and the organization of labor (P
1. Stress exposure
Indicators of the total stress level in the study groups on day “0” practically did not have differences, and the overall stress index on the IDICS scale (“V0” in Table 3) corresponded to a high level (58.1 in the study group and 55.3 in the control group) . On Day 0, students in both groups could identify the following characteristics of occupational stress:
• impeding external circumstances (poor working conditions, problems in the organization of the labor process and high intensity loads);
• strengthening of inadequate forms of stress relief: smoking, drinking alcohol;
• demonstration of hostile behavior characteristic of magnesium deficiency [5, 7].

When comparing the assessment of occupational stress among students of the initial level (day “0”) and after 2 months (day “60”) in the control group (second group), the subjective assessment of the professional situation worsened significantly (during the observation period, the workload increased session) (p = 0.021). The deterioration was accompanied by signs of psychological exhaustion — emotional tension, a decrease in general well-being, an increase in anxiety, signs of depression, and sleep disorders.
At the same time, in the study group that received Magne B6 therapy, despite the growing tension in studies and preparation for the session, the test index of the subjective assessment of the professional situation did not significantly change (which corresponds to the supportive effect of the drug). In addition, Magne B6 therapy reliably reduced the severity of experiences of acute and chronic stress (p = 0.022 and 0.001, respectively), which was manifested in improving the general well-being, mood, concentration of attention, remembering the necessary information. In the control group, the level of chronic stress also decreased, albeit unreliable (we believe that this is the answer to the use of placebo and the element of keeping some test questions in memory).
Most importantly, taking the drug Magne B6 led to a decrease in the severity of stress reactions. The overall stress index of IDICS in this group also decreased significantly (p = 0.001), whereas in the control group it grew. In addition, Magne B6 therapy significantly (by 30%) reduced the manifestations of personal behavioral deformities (p = 0.00001), i.e., reduced the signs of burnout syndrome and neurotic reactions (see Table 3). Students have improved performance indicators of autonomy of the tasks (autonomy). The most significant differences are summarized in fig. one.

2. Memory Functioning
On the DIAKOR scale, the parameters of aural speech, visual and motor memory were assessed. According to this scale, the functioning of memory was evaluated inversely as the number of so-called “Penalty points”, i.e., the lower the score, the more effectively memory operates. Almost all parameters of all three types of memory showed significant improvements in the group that took Magne B6, compared to the control.
a) When evaluating the parameters of hearing-speech memory on the day “60”, students of both groups improved the integral indicator of hearing-speech memory (p 6) by the end of the treatment course the changes were higher than in the control group: the integral memory indicator on the DIAKOR scale improved by 2.55 against 2.42 times, respectively (P 6, the best results were obtained in combining various stimuli into holistic semantic structures, i.e., the ability to analyze and synthesize information. In the group of students who took Magne B6, penalty points for combining incentives into holistic thought structures decreased from 1.16 to 1.02 (R b) When evaluating the parameters of visual memory on day 0, no significant changes were detected in the comparison groups (p> 0.05). On the day 60, students in the control group there was an improvement in the volume of direct visual memory on the IDICS scale (p = 0.05), the other parameters did not significantly change (Table 4).
At the same time, in the group of students who took Magne B6, the data obtained on day 60 indicate a pronounced and, most importantly, significant improvement in the integral index of visual memory (5.4 times, p in). In a comparative assessment of the parameters of the motor memory of the studied group on day “0” and dynamic parameter estimation in the second group (control) no significant changes were detected (p> 0.05). The students of the studied group significantly improved the integral index of motor memory (p = 0.0035, 2.3 times versus 1.9 times as compared with the control group) due to a significant increase in the amount of direct memory (5 times, p = 0.014) ( Table 5).
Differences in the integral indices of different types of memory are summarized in Fig. 2
Thus, the course dose of the drug Magne B6 improves the parameters of the visual, auditory and motor memory. Improving the parameters of both visual and auditory memory is related to the optimization of the work of the posterior structures of the left hemisphere, the anterior structures of the left hemisphere, the posterior sections of the right hemisphere and the anterior sections of the right hemisphere. At the same time, improving the performance of motor memory, the drug is likely to affect the work of brain structures providing interhemispheric interaction.

3. Evaluation of magnesium and vitamin B6 levels
The students of both groups had about the same level of magnesium deficiency and B6 hypovitaminosis at day 0. The two-month course of Magne B6 vitamin-mineral complex significantly reduced the total points of magnesium deficiency (p = 0.000001) and vitamin B6 (p = 0.00003), which corresponds to a significant improvement in the provision of magnesium and pyridoxine, while in the control group there is a change in indicators (Fig. 3).
Another interesting observation directly indicating the normalization of magnesium homeostasis was a significant reduction in convulsions of the gastrocnemius muscles in the study group (p 6 and 19.35% (6 out of 31) in the control group complained about the "reduction" of the gastrocnemius or foot muscles during swimming or after the pool, as well as after training in the gym. On the “60” day, in the control group, the number of students who complained of leg cramps not only did not decrease, but increased to 25.8% (8 out of 31), while as in the group of students taking Magne B6, no convulsions were observed Not a single student has an elk (Fig. 4).

findings
Thus, against the background of the course taking the drug Magne B6 noted:
1. a significant reduction in the symptoms of magnesium deficiency and vitamin B6;
2. Improving the performance of hearing, movement and visual memory;
3. reducing the experience of acute and chronic stress, reducing personal and behavioral deformities, improving muscle performance.

These results indicate that the 60-day course of the drug Magne B6 is an effective way of pharmacological correction of magnesium and vitamin B6 deficiency, which was manifested in a significant improvement in cognitive functions and, above all, memory and reduction of negative stress manifestations with high psycho-emotional stress.
Thanks. We are very grateful to the asp. I.V. Gogol, Assoc. O.A. Nazarenko, V.A. Abramova, A.S. Murinu for assistance in conducting a clinical study and a VSP. A.Yu. Gogolev - for help with mathematical data processing.


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Natural Vitality Calm, The Anti-Stress Dietary Supplement Powder, Cherry - 16 Ounces

Natural Vitality Calm, The Anti-Stress Dietary Supplement Powder, Cherry - 16 Ounces

How to fill the magnesium deficiency in the body

If in the winter you are accustomed to catch up with apathy and irritability, do not rush to blame the weather. More like that you do not have enough magnesium - a trace element that plans to push vitamin C from the post of the chief health officer.

The human body is a powerful chemical laboratory that works without holidays and weekends every second of life. For thousands of reactions constantly need vitamins, trace elements, water, fatty acids, glucose. As in any industry, some substances are needed quite a bit, and even if they are not in stock, no one will die: they will replace, synthesize, postpone the reaction until better times. But some elements are needed all the time, and their shortage can stop the work of the enterprise. It’s like in the restaurant’s kitchen: a good chef will manage without capers or lime leaves, but if you don’t have salt or oil on hand, the establishment will not last long.

Magnesium Magnesium
The most popular vitamins and microelements in the lab called “man” are vitamin C, potassium, sodium, calcium, iron and magnesium. The latter keeps a little apart by chance: compared with colleagues, it is not so easy to get from food. First, magnesium champion products are not very popular. Remember how often you personally eat rice bran, seaweed, pumpkin or watermelon seeds? Secondly, in cereals, leafy greens, nuts, which are considered to be good sources of magnesium, every year less and less of this element. This is due to the depletion of the soil and aggressive farming: the introduction of some fertilizers reduces the content of vitamins, micro and macro elements and antioxidants in plant foods. According to the US Food and Drug Administration (FDA), over the past
For 50 years, vegetables and fruits have become 30–50% less valuable from the point of view of mineral substances. Another reason to talk about magnesium is that its consumption increases markedly in the event of stress. A rare resident of the metropolis can boast that he lives without emotional shocks, physical and intellectual stress, lack of sleep, fast food, and all this causes the body to spend more magnesium for the body to work properly.

Will not find it
A serious magnesium deficiency is difficult not to notice: literally all organs and systems will signal this. The element is necessary for muscle and nervous relaxation - it helps to relax the blood vessels and heart muscle, soothe in stressful situations. If there is a shortage of magnesium, the person will quickly experience symptoms such as high blood pressure, tachycardia, tearful or depressive state. Magnesium also helps to assimilate the most important for health vitamin D, participates in the formation of the bone skeleton and lipid metabolism, is necessary for the normal course of pregnancy. It is also important that in a situation when a person does not receive 320-500 mg of a substance necessary for him every day with food, the body begins to take magnesium from the bones - its main reserves are stored there. Such crediting will not lead to anything good: efforts to exchange will be spent a lot, and the result will be only a short-term improvement in the general condition of the person and the fragility of the bones in the future.

Out of range
It is considered if a person fully and variedly eats, does not experience increased physical and emotional stress, and does not carry a child, he only needs magnesium, which is ingested with food and water. But in reality, experts of the World Health Organization claim that about 75% of the inhabitants of industrialized countries receive less than the recommended daily dose of this element, and most of them are satisfied with only 10% of the required amount. Plus, even those crumbs that enter the body with nuts, seeds, seafood, meat, are often poorly absorbed due to the genetic characteristics of a particular person, diseases of the gastrointestinal tract and diets with a large amount of calcium and protein - these substances prevent the absorption of magnesium.

That is, ever-losing weight lovers of cottage cheese and chicken breast in a particular risk group: chronic fatigue and bad mood may well be companions of their diet precisely because of the incomplete absorption of magnesium. Sweet tooths are also unlucky: excessive sugar consumption worsens magnesium metabolism, and its lack, in turn, threatens insulin resistance and the development of various forms of diabetes.

Refer to the sources
We can do nothing with the quality of modern products, but we can change a lot in our own way of life, so as not to suffer from magnesium deficiency. Step one is to remember that this valuable element can be obtained not only from food. The largest organ of the human body, the skin, is able to absorb it directly. Therefore, baths with English salt is a good way to help your nervous system recover from a hard day. By the way, this bath also contributes to detoxification of the body, so before swimming it is recommended to drink a couple glasses of water.

The second stage of magnetization is to take dietary supplements with this element in the composition, after consulting with a doctor. The recommended daily intake is 320 mg, for women over 30, it can be increased to 400 mg. Since not all forms of magnesium are equally well absorbed, endocrinologists recommend taking it in the form of citrate or glycinate. But you shouldn’t hope for supplements only: the human body prefers to receive necessary substances from food. The good list of foods rich in magnesium is very appetizing: here and avocado with dried apricots, and spinach with soy, and sea fish with sesame, and buckwheat with quinoa.

Top 10 magnesium deficiency symptoms

Cramps, especially at night and after exercise. Tingling and numbness in the arms and legs.
Feeling of chronic fatigue, lack of energy in the morning after a long sleep.
High blood pressure.
Crying, irritability, increased manifestations of PMS.
Edema, fluid retention, constipation.
Indistinct eyesight, nausea, loss of coordination, clouded consciousness.
The sharp deterioration of the skin, hair and nails.


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Magnesium Glycinate Complex 450 mg Tablets - Formulated for Calm, High Absorption, Muscle Relax & Gentle Digestion, Vegan, Non-GMO, Gluten-Free, Soy Free, Bioavailable, 180 Tablets

Magnesium Glycinate Complex 450 mg Tablets - Formulated for Calm, High Absorption, Muscle Relax & Gentle Digestion, Vegan, Non-GMO, Gluten-Free, Soy Free, Bioavailable, 180 Tablets

Magnesium sulfate: instructions for use

Pharmaceutical action

Magnesium is able to displace calcium from its binding sites, as it is a physiological calcium antagonist. Magnesium regulates metabolic processes, muscular excitability and neurochemical transmission, prevents the passage of Ca2 + ions through the presynaptic membrane, reduces the content of acetylcholine in the central and peripheral nervous system. The intracellular deficiency of Mg2 + ions provokes the development of ventricular arrhythmias. When injected, magnesium sulfate blocks the neuromuscular transmission (in large doses, the drug has curare-like properties) and prevents the development of seizures, dilates the peripheral vessels, reduces the pulse rate and slows down AV conductivity. Injections of low doses of magnesium sulfate cause only sweating and hot flashes, high doses cause a decrease in blood pressure.
Magnesium sulfate has a depressant effect on the central nervous system. Depending on the dose administered, sedative, hypnotic, and even general anesthetic effects can be observed.
Magnesium sulfate reduces the excitability of the respiratory center, large doses of the drug can lead to respiratory paralysis. Magnesium sulfate when poisoning with salts of heavy metals is an antidote.
Systemic effects with intramuscular injection develop after 1 hour, with intravenous administration almost instantly. The duration of the drug when administered intramuscularly is 3-4 hours, with the introduction of intravenous - about 30 minutes.
When used orally, the drug promotes the release of cholecystokinin, has a choleretic effect, irritates the duodenal receptors. Magnesium sulfate is poorly absorbed, not more than 20%, increases the osmotic pressure in the gastrointestinal tract, retains fluid and, by a concentration gradient, facilitates its release into the intestinal lumen, increasing peristalsis in all intestinal sections, 4 to 6 hours after ingestion leads to defecation. The absorbed part of magnesium is excreted by the kidneys, and diuresis increases. The drug passes through the placenta and the blood-brain barrier, is found in breast milk, and its content is 2 times higher than in the mother's blood plasma.
Indications

For injection: hypertensive crisis (including with signs of swelling of the brain); encephalopathy; eclampsia; hypomagnesaemia, including for prevention (unbalanced or inadequate nutrition, diuretics, contraceptive use, chronic alcoholism, muscle relaxants); acute hypomagnesemia (myocardial dysfunction, signs of tetany); increased need for magnesium (pregnancy, stress, recovery period, growth period, excessive sweating); the threat of preterm birth; convulsions during preeclampsia; ventricular tachycardia type "pirouette"; ventricular arrhythmias that are associated with an increase in the QT interval; the occurrence of arrhythmias at low plasma concentrations of magnesium or / and potassium; urine retention; epileptic syndrome; poisoning with salts of heavy metals (arsenic, mercury, lead).
For oral administration: constipation; cholecystitis; gallbladder dyskinesia of hypotonic type (for tubing); cholangitis; bowel cleansing before diagnostic procedures; duodenal intubation (to obtain a cystic portion of bile); poisoning with salts of heavy metals (arsenic, mercury, barium, lead).
Contraindications

Hypersensitivity, hypermagnesia. Additionally for injections: arterial hypotension, severe bradycardia, depression of the respiratory center, AV blockade, prenatal period (2 hours before delivery), severe renal failure (with creatinine clearance less than 20 ml / min). Additionally for oral administration: appendicitis, intestinal obstruction, rectal bleeding (including intended), dehydration.
Dosing

Magnesium sulfate is injected intramuscularly, intravenously, taken orally. Intravenously (slowly, the first 3 ml - enter 3 minutes) or intramuscularly - 5–20 ml of a 20–25% solution every 1-2 times a day. In case of poisoning with arsenic, mercury, tetraethyl lead - intravenous 5–10% solution of 5–10 ml. To relieve convulsions in children intramuscularly 20–40 mg / kg (or 0.1–0.2 ml / kg of a 20% solution). The maximum dose of magnesium sulfate is 40 g / day (160 mmol / day).
Inside: as a laxative (on an empty stomach or for the night) adults - 10–30 g in half a glass of water, children —1 g for 1 year of life; for cholagogue - 1 tablespoon of a 20–25% solution 3 times a day; for duodenal sounding, 100 ml of 10% solution or 50 ml of 25% solution is injected through a probe.
Poisoning with soluble barium salts: wash the stomach with 1% magnesium sulfate solution or take it inside with 200 ml of water 20-25 g.
With prolonged treatment with magnesium sulfate, it is recommended to monitor the work of the heart, blood pressure, tendon reflexes, respiratory rate, kidney function. If it is necessary to simultaneously use intravenous calcium and magnesium preparations, then they should be injected into different veins. Patients with severely impaired renal function should not receive more than 20 g of magnesium sulfate for 2 days; also the patient (and also patients with oliguria) should not be given intravenous magnesium sulfate too quickly.
Side effects

When administered parenterally: the symptoms and signs of hypermagnesemia - diplopia, bradycardia, flushing, hypotension, sweating, depression of the central nervous system and heart, with a content of Mg2 + 2-3.5 mmol / l in the blood - a decrease in deep tendon reflexes; 2.5–5 mmol / l - expansion of the QRS complex and prolongation of the PQ interval on the ECG; 4–5 mmol / l - the absence of deep tendon reflexes; 5–6,5 mmol / l - depression of the respiratory center; 7.5 mmol / l - disturbances of cardiac conduction; 12.5 mmol / l - cardiac arrest. Hypothermia, atony of the uterus, weakness, headache, anxiety, hypocalcemia with signs of secondary tetany can also develop. With a very high plasma concentration of magnesium (which can occur, for example, with a very fast intravenous drug, with renal failure): polyuria, paresthesia, nausea, vomiting.
When ingestion: nausea, diarrhea, vomiting, exacerbation of inflammatory diseases of the digestive system, thirst, spastic abdominal pain, flatulence, electrolyte imbalance (asthenia, fatigue, confusion, convulsions, arrhythmia), symptoms and signs of hypermagnesium (especially in the presence of renal failure).
Interaction

The use of nephrotoxic drugs such as cisplatin, amphotericin B, gentamicin, cyclosporin, increases the need for magnesium. Thiazide and loop diuretics with prolonged use can reduce the magnesium-preserving function of the kidneys, this can lead to hypomagnesemia (control of the content of magnesium in the blood is necessary). Potassium-sparing diuretics with prolonged use increase the reabsorption of magnesium in the kidneys, this can lead to the development of hypermagnesia, especially in patients with renal insufficiency. Calcium salts (for intravenous administration) relieve the effects of magnesium sulphate used parenterally. But calcium chloride or calcium gluconate is used in hypermagnesia to eliminate toxic effects. The combined use of oral calcium supplements and magnesium sulfate can cause an increase in serum magnesium or calcium, especially in patients with renal insufficiency. The deprivation effect on the central nervous system with parenteral use of magnesium sulfate is enhanced when combined with drugs that have a depressant effect on the central nervous system. There is information about the development of hypomagnesemia in patients who simultaneously used digitalis glycosides and magnesium sulfate, and this can cause digitalis intoxication. When administered orally together, magnesium sulfate may reduce the absorption and content of glycosides in the blood in digitalis. Muscle relaxants increase neuromuscular blockade when taken together with magnesium sulfate. Magnesium sulfate reduces the absorption of tetracyclines, etidronovoy acid. Excessive glucose or alcohol increases the renal excretion of magnesium.
special instructions

Restrictions on the use of

For injections: myasthenia gravis, respiratory diseases, chronic renal failure and other disorders of the kidneys, acute inflammatory diseases of the gastrointestinal tract.
For oral administration: myocardial damage, heart block, chronic renal failure.

Use during pregnancy and lactation

If there is a need to use magnesium sulfate during lactation, then breastfeeding should be stopped. Animal studies using magnesium sulfate have not been carried out. It is not known whether magnesium sulfate has an adverse effect on the fetus or whether the drug affects the reproductive capacity. Therefore, use magnesium sulfate during pregnancy only if necessary.
With parenteral use during eclampsia in pregnant women, the drug quickly penetrates the placenta and in fetal blood serum reaches approximately the same concentration as that of the mother. In newborns, the effects of magnesium sulfate are similar to those of the mother and may include hyporeflexia, respiratory depression, hypotension, if the woman received magnesium sulfate before delivery. Therefore, usually in the prenatal period (2 hours before delivery) magnesium sulfate is not used, except in cases when it is necessary to prevent convulsions during eclampsia. Magnesium sulfate can be administered continuously intravenously at a rate of 1–2 g every hour, provided that the patient is carefully monitored (plasma magnesium concentration, blood pressure, respiratory rate, deep tendon reflexes).

Overdose

In case of an overdose of magnesium sulfate when administered parenterally, there are: the disappearance of the knee jerk (the classic clinical symptom of the onset of intoxication), nausea, a sharp decrease in blood pressure, bradycardia, vomiting, depression of the central nervous system and respiration.
Necessary: ​​as an antidote, calcium preparations (calcium gluconate or calcium chloride 5–10 ml 10%), intravenous inhalation of carbogen, oxygen therapy, artificial lung ventilation, hemodialysis or peritoneal dialysis, symptomatic therapy (correcting the cardiovascular and central nervous system) are slowly administered intravenously. ).


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Natures Plus Animal Parade Sugar-Free MagKidz Childrens Magnesium Supplement - Natural Cherry Flavor - 90 Chewable Animal Shaped Tablets - Bone & Muscle Health Support - Gluten Free - 45 Servings

Natures Plus Animal Parade Sugar-Free MagKidz Childrens Magnesium Supplement - Natural Cherry Flavor - 90 Chewable Animal Shaped Tablets - Bone & Muscle Health Support - Gluten Free - 45 Servings

Magnesium for your health and wellness

Magnesium is of great importance for mental and physical health.

The human body is a complex organism, the proper functioning of which depends on a variety of vitamins, minerals and other nutrients. Unfortunately, the modern diet lacks many essential nutrients. Manufacturers of dietary supplements often ignore magnesium , despite the fact that it is extremely important for overall health.

Although magnesium is less commonly spoken of, it is one of the most abundant minerals in the world. In nature, magnesium is found, for example, in the form of magnesium chloride in the ocean or pure magnesium in plant chlorophyll. It is the second most common element in the cells of the body, hundreds of biochemical reactions in the human body occur with the participation of magnesium. In the form of a positive ion, magnesium regulates enzyme systems. This means that magnesium is involved in most of the vital functions of the body.

The main role of magnesium in the human body is to regulate the enzymes that send chemical signals throughout the body. Being an enzymatic cofactor, magnesium activates enzymes and contributes to their proper participation in enzymatic reactions. It is necessary for the normal functioning of ATP molecules, which are the source of energy in the human body. Magnesium is involved in the conversion of sugar and fat into energy, in the construction of DNA, in the reduction of muscle fibers, in the construction of new cells, in the assimilation of mineral substances, and in the regulation of cholesterol levels. The important role of magnesium causes the need for it for the normal functioning of all organs, bones and muscles in the human body, and the level of magnesium content affects many aspects of health.

One of the most important functions of magnesium is its effect on muscle contraction. Magnesium is responsible for the relaxation of muscle fibers after their reduction. Thanks to this you can make certain movements. Magnesium prevents cramps caused by prolonged muscle contraction. Without magnesium, which feeds your muscles, you feel weak and lethargic after such physical activities as climbing stairs.

The bones of the body are constantly updated through the process of homeostasis of osteoblasts and osteoclasts. Magnesium not only helps regulate bone homeostasis, but also ensures proper absorption of vitamin D and calcium, essential for healthy bones. A 2010 study, published by Biological Trace Element Research, found that magnesium supplements can prevent osteoporosis in older women.

Receiving magnesium helps to prevent many other diseases. It helps to reduce cholesterol, reduce blood pressure and maintain muscle contractions, so we take a certain amount of magnesium is useful for cardiovascular diseases, stroke and heart rhythm disorders. It also plays an important role in glucose metabolism, which affects blood sugar levels. Inadequate magnesium intake increases the likelihood of getting type 2 diabetes.

Due to the fact that magnesium is involved in the chemical reactions of the body, it also affects the brain and neurotransmitters, on which our mood depends. Thus, magnesium can help improve your mental state. According to a 2010 study, depressive conditions that are not amenable to treatment with traditional drugs can be improved with magnesium. Magnesium appears to be beneficial in preventing or treating depression due to its role in the synthesis of hormones and neurotransmitters. It provides the brain with the necessary amount of dopamine and other chemicals that cause a feeling of satisfaction to counteract depression. Depression is so strongly associated with magnesium deficiency that some mental health experts put forward a theory that depression has become more common due to inadequate intake of whole grains rich in magnesium.

Depression is perhaps the most dangerous mental disorder, but magnesium deficiency causes other diseases, such as insomnia and anxiety neuroses. Magnesium helps calm the brain by blocking the excessive activation of NMDA receptors. Constant activation of these receptors causes the deterioration of neurons, and this can even lead to cell death. The most important protective role of magnesium in the brain is that the brain is able to relax, relax and process information.

Magnesium also affects mental disorders because it plays an important role in the production of hormones. Certain stress hormones, such as cortisol and adrenaline, are formed when the adrenal glands are activated. Magnesium helps to suppress and slow down the activation of the adrenal glands, protecting the body from an excess of these hormones that increase blood pressure, anxiety and stress. Lack of magnesium can cause increased stress, and long-term stress can lead to a decrease in magnesium levels due to fatigue of the adrenal glands. For this reason, it is important to limit the duration of exposure to stress and increase magnesium intake, including in the diet minimally processed foods.

Even if you do not suffer from serious mental disorders, you will benefit from a soothing magnesium bath , which will help to improve your mental mood when signs of stress or depression appear. Lack of magnesium can cause confusion in thoughts and mental disorders, because the brain has problems with storing and processing information with a lack of neurotransmitters and energy. In general, magnesium is needed to optimize brain function.

Due to the positive effect of magnesium on the state of health, its use is used to treat many different diseases. The American Heart Association recommends that magnesium be administered intravenously to patients who have an arrhythmia. The study also showed that magnesium supplements can be used to treat eclampsia, a disease that occurs during pregnancy and can cause health attacks. A number of studies show that even some of the symptoms of alcoholism can be alleviated when patients take magnesium.

As we can see, magnesium is a very important mineral, but its role in biosynthesis is often overlooked. Unfortunately, a 2014 study published in the International Journal of Laboratory Medicine showed that 2.5 to 15% of the population is deficient in magnesium. This condition, known as hypomagnesemia, is fairly common because processed foods, which make up the bulk of the diet of many people, do not contain magnesium. Magnesium deficiency is also caused by drugs that are proton pump inhibitors, which are used to treat gastric reflux. People suffering from Crohn's disease, type 2 diabetes, alcoholism, celiac disease, regional enteritis also have a higher risk of developing magnesium deficiency.

At first, signs of moderate magnesium deficiency are hardly noticeable, but over time hypomagnesaemia causes serious problems. People with a slight magnesium deficiency feel tired, weak, irritable, and nauseous. If inadequate intake is replaced by an almost complete lack of magnesium intake, then symptoms such as severe muscle contractions, convulsions, arrhythmia, personality restructuring, and numbness appear. These signs of a dangerous magnesium deficiency can be life-threatening, but even less serious deficiency can cause health problems.

You may have a magnesium deficiency if you notice the following symptoms:

Regular muscle cramps and cramps
Recently identified cardiovascular diseases
Difficulty falling asleep or having trouble sleeping
Slight trembling in arms and legs
Difficulty remembering
Stable high blood pressure
Excessive anxiety or depression
Diagnosed with type 2 diabetes
Lack of other minerals
Feeling weak during daily physical activity
Inability to concentrate

To get rid of these symptoms, you need to make sure that your body gets enough magnesium from food or supplements. The daily need for magnesium increases with age, because the body is less efficient in absorbing magnesium as it ages. Although men usually need more magnesium than women, the need for pregnant women is also high. Children need about 240 mg per day. Men under 30 need about 400 mg per day, but with age, the need rises to 420 milligrams. Women under 30 usually need about 310 milligrams per day, and if they are pregnant, the need is 360 milligrams per day.

Fortunately, you can increase the level of magnesium in your body. Since it is easily absorbed through the skin, you can daily rub cream with magnesium to satisfy the need for magnesium without changing your diet. English salt also contains magnesium , so bathing with English salt can increase magnesium levels.

Magnesium can be found in various plant products, because it is an important element of chlorophyll, which is involved in the process of photosynthesis. Green leafy vegetables such as cabbage, spinach and kale are high in magnesium, and magnesium is also found in whole grains, nuts, and beans. There are also many tasteless liquid magnesium supplements that can be added to drinks and cocktails to increase the level of magnesium in the body without changing your diet.

Magnesium is an important mineral that is involved in almost all functions of the human body. Regardless of the source of magnesium you choose, it’s important that you fill your needs for it every day. This mineral not only strengthens your bones, organs and muscles, but it is very important for brain health. Inadequate intake of magnesium can lead to mental illness, cardiovascular disease, sclerosis, diabetes and even beriberi. Pay attention to muscle cramps, weakness, sleep problems, severe stress or depression, and other signs that your body may receive less of this mineral. In order to avoid magnesium deficiency, be sure to consume the recommended daily dose, for this it is convenient to take a dietary supplement.

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Superior Labs Magnesium Citrate - 100% NonGMO Safe from Additives, Stearates, Gluten and Other Allergens - Powerful Dose for Sleep, Headaches, Cramps, Twitches - 1,250mg Citrate, 120 Vegetable Caps

Superior Labs Magnesium Citrate - 100% NonGMO Safe from Additives, Stearates, Gluten and Other Allergens - Powerful Dose for Sleep, Headaches, Cramps, Twitches - 1,250mg Citrate, 120 Vegetable Caps

Familiar with macro and microelements: magnesium

Antistress mineral, the second intracellular cation after potassium. Component of chlorophyll plants. Where the soil is rich in magnesium (on the banks of the Nile), malignant tumors are very rare. And in those areas of the globe where it is not enough (some areas of the UK), malignant tumors are more common. Magnesium balance is regulated by the kidneys.

Daily need

Adults: 280–400 mg (approximately 4.5 mg per 1 kg of body weight). Children need more than adults (as there is a constant increase) - about 6 mg per 1 kg of body weight: children under 3 years old - 50–150 mg, 4–6 years old - 200 mg, 7–10 years old - 250 mg, 11-17 years old - 300 mg.

Lactating women should additionally receive 60 mg of magnesium to compensate for its loss with breast milk. According to other sources: pregnant and lactating - about 350-450 mg.

With kidney disease - more than 3000 mg of magnesium per day is not recommended.

The need for magnesium increases in the following cases:

in children and adolescents, people of elderly and senile age;
caffeine intake (tea, coffee, chocolate, pepsi-cola);
when used sugar: magnesium affects the metabolism of insulin, and sugar increases the loss of magnesium in urine;
a large amount of fat in the diet reduces the absorption of magnesium, since fatty acids and magnesium form salts that are not absorbed in the gastrointestinal tract;
high-protein diet, especially in children, athletes, during pregnancy and lactation;
colitis, constipation, cirrhosis, pancreatitis, uncontrollable vomiting, diarrhea;
with increasing cholesterol in the blood;
thyrotoxicosis, parathyroid hyperfunction, renal acidosis, epilepsy;
after high-temperature diseases;
after operations;
with heavy physical exertion;
in the use of contraceptives and estrogens;
chronic alcoholism. Alcohol more than any other of the known substances contained in food, reduces the magnesium content in the blood. Even with moderate alcohol intake, magnesium deficiency gradually develops.

In alcoholics, it is manifested by muscle weakness and myocardial damage.
Value in the body

Magnesium is closely associated with the synthesis and use of ATP, therefore it has an exceptional effect on the body's energy metabolism.

About 300 enzymes participate in the work. Magnesium is necessary for the activation of enzymes in 50% of cases.

Anti-toxic and anti-inflammatory factor.

In cardiomyocyte, it participates in the conjugation of arousal of contraction-relaxation and thus ensures the health of the cardiovascular system.

Normalizes the function of the parathyroid glands.

Regulates temperature, helps to adapt to cold.

Building material for lung tissue.

Required to strengthen the skeleton and prevent osteoporosis.

Necessary for the normal functioning of the nervous tissue, is involved in the transmission of nerve impulses, calms the central nervous system, helps in the fight against depression. If the nerve cells have not yet died, but only suffered, then, having received their portion of magnesium, they will be actively restored.

Prevents kidney stones.
Relationship with other trace elements

The presence of magnesium reduces the risk of the toxic effect of heavy metals by 30%.

It is a natural and physiological partner of calcium, competing with it at all levels of the cell and in the process of absorption in the intestine. The ratio of calcium to magnesium should be 2: 1.

The introduction of magnesium can increase the intracellular content of potassium due to the activation of ATP, which inhibits the loss of potassium by the cell. With a lack of intracellular magnesium begins the loss of cellular potassium. In response to the release of potassium from the cell, sodium begins to flow into it, reducing its energy.
Use in medicine

Prevention and treatment of various forms of angina.
Prevention of metabolic changes caused by myocardial ischemia.
Prevention of hyperparathyroidism.
Interferes with blood vessel calcification, but magnesium should work together with calcium.
When drunk to alleviate or prevent hangover.

Initial signs of magnesium deficiency

Palpitations, arrhythmias or tachycardias, often accompanied by severe, piercing chest pain, changes in blood pressure in any direction; magnesium deficiency contributes to atherosclerosis. Heart rhythm disturbances, neurocirculatory dystonia, and coronary heart disease develop.

Insomnia, nightmares, night sweats, heavy awakening, tearfulness, and even bouts of anguish.

State of anxiety, anxiety, nervousness, fear, violation of skin sensitivity.

Fatigue, frequent headaches, difficulty concentrating; sudden dizziness, loss of balance; morning tiredness, even after a long sleep. Feeling of heaviness in the body.

Hair loss, brittle nails, tooth decay.

Sensitivity to changes in weather, to cold and humidity, often causing various pains of teeth, gums, joints.

Decreased body temperature, cold hands and feet, stiffness of the limbs, tingling in the legs, spasms.

Twitching eyelids; fog, twinkling dots before eyes.

Enhanced start-reflex ("jumping"), impatience, the desire to do at the same time a lot of things that a person starts and does not end.

In further concern:

acute, antispasmodic pain in the stomach, often accompanied by diarrhea; chronic diseases of the gastrointestinal tract;
muscle spasms, muscle twitching (tetany), tremor, sore pain or muscle tension;
anemia (due to the destruction of red blood cells);
trophic ulceration;
calcification of tissues characteristic of hypercalcemia, but against the background of normal calcium content;
formation of thymomas: the thymus gland mass increases, immunity is disturbed.

A deficiency of calcium and magnesium worsens the course of allergic diseases.

During an attack of bronchial asthma, magnesium is deficient in the blood.

Low levels of magnesium are often found in patients with diabetes, which leads to the destruction of the body. An increase in magnesium normalizes blood sugar.
Consequences of deficiency for pregnant women

Arrhythmias, cardiomyopathy, eclampsia.
Consequences of deficiency for newborns

Heart defects and blood vessels.
Consequences of deficiency for children

Rickets, lethargy, tremor, laryngo-and bronchospasm, contraction of small muscle groups. The development of atherosclerosis from childhood is characteristic.
Sources

Aloe vera, hawthorn, white grapes, pepper, zherukha, nettle, lemon balm, parsley, black chokeberry, spinach, chlorella, vegetable greens, skullcap, cocoa, pine, almond and hazelnut, pumpkin seeds and sunflower seeds, soybean, wheat bran, cereals (whole grains), beans, fresh leafy greens, as well as peas, crabs, shrimps, clams, liver, oats, rye bread, apples, figs, lemons, grapefruits, grapes, dogrose, pumpkin, garlic, mineral water with magnesium .

The amount of magnesium in foods depends on its content in the soil. By grinding the grain 80% of magnesium is removed.


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Nature Made High Potency Magnesium 400 mg - 150 Liquid Softgels

Nature Made High Potency Magnesium 400 mg - 150 Liquid Softgels

Calcium plus magnesium preparations. Preparations of potassium, calcium and magnesium. An excess of elements is as dangerous as their lack.

Age, ecology and lifestyle - the main factors that affect the performance of internal organs. If the issues of ecology of the environment and a healthy lifestyle a person can decide on their own, then time is beyond the control of anyone. With age, all processes in the body slow down and lose their former effectiveness, and the organs are increasingly beginning to falter. The main internal organ is rightfully considered to be the heart, which, with proper care throughout life, is able to work an impressive length of time.
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The Academy of Natural Healing is a specialist in whole health in 12-18 months. If you liked this article, we would be very happy to receive a small contribution for our activities! Diabetes pregnancy can lead to significant risks for the mother and baby. For this reason, strict control measures are necessary for patients.

For the prevention of cardiovascular diseases, you should get rid of bad habits , keep your weight in the normal range and help the body with medication. With the latter copes containing potassium and magnesium. In this article, we will consider the beneficial properties of these substances, their role in the vital activity of the organism, and we will give examples of optimal drugs that are distinguished by a high indicator of effectiveness.

When it comes to calcium, most people immediately think of milk, cheese, cottage cheese and yogurt. But calcium is not only found in dairy products. However, sufficient sunlight is required. Do you believe only in what can be confirmed by scientific research?

With the osteoporosis slogan - every third woman suffers trying to calm fears and sell calcium pills. Osteoporosis refers to porous bones that break too easily. In addition to more than 70 microelements, the Sango sea coral provides, in particular, calcium and magnesium - two basic minerals that are known to have extremely beneficial properties for our health.
What is the body for vitamins potassium and magnesium?

Preparations of potassium and magnesium perform a number of useful actions to ensure the safe operation of the heart. Each of the components is responsible for individual tasks, which together result in a significant reduction in the risk of cardiovascular diseases.
Potassium

In addition to a positive impact on the work of the cardiac system, potassium normalizes the functioning of the intestine, leads to a balance of water-electrolyte ratio and is actively involved in the process of metabolism. Potassium helps the body produce protein and transform glucose into glycogen.

Magnesium deficiency affects all of us. Study the multiplicity of causes of magnesium deficiency and then prevent magnesium deficiency. One day Japanese Shigechiyo Izumi was supposed to interview a British journalist. Few people know how important vitamin K is for their bodies. Vitamin K not only controls blood clotting, but also activates bone formation and protects against cancer.

Magnesium, the most common mineral in the body, plays an important role in the activation of more than 300 chemical reactions. Again and again, vegans from the so-called experts should say that their vegetarian method of nutrition represents a huge risk for bone diseases.

An adult needs 3-5 grams of potassium daily. The dosage depends on the lifestyle and the availability of regular physical activity. The average person does not take the norm from a regular meal, so it is advisable to use vitamins potassium, magnesium and calcium tablets.

Most potassium is found in dried apricots, raisins, peas, bananas, watermelons and kiwi.

Milk and dairy products have always been evaluated as high-value protein, vitamin and mineral supplements in advertising. Calcium, along with magnesium, is the most famous mineral. Calcium is also a mineral that is often ingested in the form of tablets or powder.

Finding the best source of calcium is not easy. Because the choice is very large. The best known sources of calcium are calcium citrate and calcium carbonate. And magnesium is closely related to its effectiveness. This aspect of cholecalciferol often remains a missed error. To transport the vitamin in the body, magnesium serves as a transport molecule as a fuel. If it is too long, the body's healthy self-regulation is excluded.
Magnesium

Magnesium allows you to increase energy reserves in the body, due to the splitting of glucose. It plays an important role in many enzymatic processes associated with the restoration of cells and their protection from damage. Magnesium increases the absorption of B vitamins.

In tandem with calcium, he leads the work of blood vessels in tone and prevents their diseases. Magnesium and calcium interact harmoniously, enhancing the positive effects of each other. Preparations containing potassium, magnesium and calcium strengthen bones, cartilage, teeth, nails and hair, and also contribute to the normalization of blood pressure.

The alleged disease is associated with a strong magnesium deficiency. An increase in vitamin absorption leads to an increase in magnesium excretion. As a side effect, absorption of magnesium is increased through the intestines, which does not compensate for excretion. Each individual development requires certain enzymes that depend on magnesium. Without this, it is impossible to carry out the metabolism of the vitamin and develop the effect. The same applies to an excessively high amount of magnesium.
Magnesium is 400 mg per day.

Healthy adults need a daily dose of 400 milligrams of magnesium. There are several possibilities to satisfy this day. The natural way is the consumption of food. Whole grains, amaranths, pumpkin and sunflower kernels, some seaweed, sesame, chocolate and nuts provide a concentrated amount of magnesium. 100 g of sunflower seeds contain 420 mg of magnesium.

An adult needs to consume 350-450 mg of magnesium daily. It is present in cabbage, nuts, seafood and cereals.
What is dangerous excess and lack of potassium and magnesium?


Any medication is useful only if you strictly adhere to the prescribed dosages and multiplicity of techniques. Self-treatment often leads to a complication of the situation, so the decision to start a course of a drug should be made on the basis of the recommendations of the doctor.

For food additives, the ingredients "magnesium gluconate" or "acetate" are necessary. These forms have better usability than other means. For this purpose, there are oral and transdermal solutions. Oral supplements are in the form of tablets, capsules, solutions and powder mixtures.

Transdermal means absorption through the skin using magnesium baths or oils. Pharmacies and supermarkets contain more than 20 active ingredients of magnesium. Magnesium does not consist exclusively of chemicals, but requires a binder partner in the form of salt. These drugs are distinguished by the content of elemental magnesium, bioavailability, side effect of the binding partner and their laxative effect. To not have the opposite effect or show additional symptoms, you must follow the advice of a doctor.

Important! Potassium and magnesium tablets do not increase their effects at high dosages. On the contrary, excess of norms is fraught with serious consequences, even lethal.
Excess potassium

The maximum rate of potassium per day - 6 grams. If the body enters more than 15 grams per day, it is possible cardiac arrest. Before starting a long course of potassium-containing drugs, you should be examined and consulted by a doctor. Since in some diseases the body initially contains high levels of the substance. In this case, the additional use of drugs can not help but harm. An excess of potassium is characteristic of the following diseases:
Transdermal absorption little studied

If free choice is available, magnesium citrate and glycinate are the best all-round forms. Magnesium transdermal absorption is not supported by any clinical study. Alternative doctors suggest that this type of intake is higher than oral administration. Large oral doses have a laxative effect and cause a further drawback.

For transdermal absorption, the patient is bathed in magnesium salt. It dissolves in water, due to which a high concentration is deposited directly on the skin. The consistency is perceived by patients as fat, so they are called "magnesium oil".

renal failure;
type II diabetes;
radiation exposure.

The course of the drug lasts from 1 to 3 months depending on the nature of the existing disease. With long-term use of high dosages, negative consequences are possible:

anxiety, insecurity, irritable state;
loss of muscle tone, heart rate failure;
bowel discomfort;
diarrhea;
diabetes.

Excess magnesium

The maximum daily dosage of magnesium is 800 mg. Excess of the established norms does not threaten a lethal outcome, but is fraught with the formation of kidney stones, the appearance of psoriasis and hyperthyroidism.

Food supplements containing copper and manganese. Multi-talent for muscles and bones. The optimal supply of vitamins and minerals is an important prerequisite for the well-being and efficiency of our body. Supplying magnesium and calcium is often not optimal with an unbalanced diet. In particular, the supply of calcium in a significant part of the population does not comply with the recommendations.

The biphasic tablet with a dual cardiac system consists of two different layers due to a specially designed manufacturing process. Magnesium and trace elements of manganese and copper are gradually released and, thus, can be available to the body in the time interval from phase 1. Magnesium for normal nervous and muscular function. Magnesium is a vital mineral that the body cannot form by itself. A high degree of food processing can now lead to the fact that the amount of magnesium absorbed through food is not always optimal.
Preparations containing potassium and magnesium


Presented to your attention drugs, whose composition is optimally balanced and can effectively solve problems with the heart.
Panangin

One of the most popular drugs containing potassium and magnesium for the heart in pills. The active substance covers a complete list of possible disorders of the cardiovascular system: from arrhythmias to angina.

Magnesium promotes normal energy metabolism, as well as normal muscle function. It also supports the normal function of our nervous system. Copper and manganese to protect connective tissue and cells. Trace elements of copper and manganese contribute to the maintenance of normal connective tissue. Mangan also maintains normal bone content. In addition, copper and manganese help protect cells from oxidative stress.
Who informs me about the quality of my drinking water?

Recommended use: Take 1 tablet daily with some liquid, without chewing. Mineral waters contain more minerals than tap water? We provide answers to frequently asked questions. Here, the focus is on fluid intake of about two liters per day, which is less than mineral intake. What kind of bottled water should be bought from the region in reusable bottles. The environment is the best.

Adequate alcohol intake is important.
Calcium, magnesium and K °, the body mainly cares about food.
Many mineral waters are rich in these substances.
Drinking water also quenches thirst.

Responsibility for the quality of your drinking water is water supply.

Basic properties:

Completion of potassium deficiency during the course of diuretic drugs that are potassium-sparing (Furosemide, Diacarb, Torasemide, etc.).
Important! When using diuretic drugs you need to know whether their effect on the level of potassium in the body. If not, then an additional reception Panangin is not required.
Normalization of heart rhythm. Panangin is used as an additional means to increase the effectiveness of the main antiarrhythmic drug.
Prevention of angina pectoris and hypertension.
Suppresses side effects from treatment with cardiac glycosides.

The drug has a wide range of contraindications, which must be read before the course.

Companies regularly check drinking water to make sure it is in excellent condition. The Drinking Water Ordinance sets limits and standards for many substances. If the load is too high, for example, nitrate or drug residues, the reasons should be eliminated. However, water is only responsible for the water clock in the house.
What is the difference between natural mineral water, healing water, spring water and table water?

Drinking water - the best proven food and good quality. Ask the water supplier about the results of the water analysis, sometimes they are also published online. Natural mineral water must be of original purity. It comes from underground, protected water pollution. It will be completed directly on the site. Mineral water is characterized by typical mineral content, trace elements or even carbon dioxide.
Aspark

Asparkam has a similar composition and properties with Panangin. The difference lies in the cost, due to a lower level of efficiency and a slower mechanism of action.
Orokamag

Another analogue of Panangin, but in capsule form. Used to combat cardiac arrhythmias. Not recommended for use by pregnant or lactating women. It has an identical list of side effects and caveats.

Source and table water are not mineral water. To them apply the limit values ​​for the regulation of drinking water. Spring water is also extracted from an underground source. However, it should not be protected from contamination. Table water is usually treated drinking water, it can be mixed with minerals and carbon dioxide. Table water can be obtained anywhere, including from different reservoirs.

Medicinal water is a medicinal product and is subject to the German Medicines Act. Its preventive or curative properties must be demonstrated by research. It should be drunk only after treatment. Mineral water is the only food that is recognized by the state. To this end, conducted numerous studies of water quality. Requirements are regulated in the rules on mineral and table waters.
Magnerot

The composition of the drug contains magnesium orotate. Each tablet contains 500 mg of the active substance.

It helps with the lack of magnesium in the body, the appearance of arrhythmias, developing angina, atherosclerosis, chronic cardiac insufficiency, myocardial infarction, muscle spasms and failures in the processes of assimilation of fat.

Side effects attributed to:
How problematic is uranium in natural mineral water?

Uranium naturally occurs in varying concentrations in the soil and is considered renal toxicity. Depending on the region and rocks, drinking or natural mineral water may also contain undesirable substances. For drinking water, 10 micrograms of uranium per liter are set as limit values. There is no general limit for mineral water. Only water “suitable for making baby food” should not contain more than two micrograms of uranium per liter.
What does “still” mineral water mean?

Your water supplier informs you about the water content in your drinking water. It does not need to point to the bottles of mineral water. Ask the manufacturer. The term "still" is not regulated by law. There is mineral water with this indicator, which contains little or no carbon dioxide. The small font should indicate whether it is naturally contained or added.

anorexia;
allergic reactions;
nausea;
diarrhea.

It is necessary to limit the use of Magnerot in the following cases:

in the presence of stones in the bladder;
with cirrhosis;
with intolerance to dairy products (lactose);
in case of failures in the assimilation of glucose.

Doppelgerz

Dietary supplement that contains a bundle of magnesium and calcium. It has a similar list of properties and contraindications, as in Magnerot.
Drugs to combat convulsions

Muscle cramps, colic, "goosebumps" are a consequence of the breakdown of the muscle-nerve connection, which can occur from a lack of magnesium in the body. An additional factor is the deficiency of vitamin B, whose production is directly dependent on the amount of magnesium. Involuntary muscle contractions occur when:

lack of fluid in the body;
diarrhea or poisoning;
use of diuretic drugs;
regular enemas;
prolonged malnutrition.

Similar symptoms are most often seen in elderly people. In their bodies, blood circulation slows down, leading to leaking limbs and cramps. The same consequences are faced by people who:

abusing alcohol;
experiencing an imbalance of macronutrients;
underwent surgery on the small intestine;
suffer from diabetes;
undergoing treatment with oncological drugs.

Cramps happen to different muscle groups. To get rid of irritable muscle contractions, it is necessary to take medicines containing magnesium and vitamins of group B.
Magne B6

The drug is available in tablet or liquid form. The composition consists of two main components: magnesium and vitamin B6. The use of medication is advisable in the following situations:

frequent muscle spasms;
arrhythmia;
pain in the stomach and intestines;
insomnia;
irritable state.

Magne B6 take a course (4 to 6 weeks). It is necessary to drink 4-8 ​​tablets 2-4 times a day during meals.

Use of funds should be limited to:

renal failure;
fructose allergy;
failure in the assimilation of glucose and sucrose.

It is also not recommended to drink Magne B6 pregnant or lactating women, as the active substance adversely affects the composition of breast milk.

Side effects include nausea, vomiting, diarrhea, and flatulence. However, all the listed symptoms are extremely rare and have a short duration.
Analogs Magne B6

The pharmaceutical market is replete with a wide list of analogues to Magne B6, which are not inferior in efficiency to the original. The main ones are:

Magnistad;
Magne Express;
Magnelis B6;
Magnesium + B6 from Systematic.

The above means have a similar list of side effects, contraindications and useful properties. Only Magnistad, which is available in the form of capsules with a special shell, is distinguished. It allows the active substance to get directly into the intestine, which greatly enhances efficiency and accelerates the mechanism of action.
Other indications for the use of such funds

Injectable form magnesium sulfate (magnesia) relieves vascular edema, reducing blood pressure. For a long period of time, the drug was used as a precautionary hypertensive crisis. At the moment, has found widespread use with increased intracranial pressure.
The magnesium sulfate powder form is a powerful laxative that removes bile from the body. A few years ago, the practice of using magnesium sulfate and hot water bottles was common, but in modern medicine, other types of laxatives are preferred.
Magnesium sulfate in droppers put pregnant women to relieve edema and relax the muscles of the cervix. For a long time, the tool was used as anesthesia, but with the development of medicine, doctors abandoned this method.

Conclusion

Funds containing magnesium and potassium play an important role in human life. First of all, they struggle with the lack of missing elements in the human body. Secondly, they often act as auxiliary means to ensure the normal functioning of the heart, intestines and stomach. Eliminate the deficiency of nutrients can not only medication, but also by adjusting your own diet. On the Internet, a lot of information about which products contain the most magnesium and potassium.

Important! Remember that the use of excessive dosages is fraught with complications. Before starting a course of treatment, be sure to consult with a qualified doctor. An experienced specialist will establish the optimal dosage and multiplicity of techniques, as well as tell you what products should be consumed in order to achieve positive results as soon as possible.

When choosing a drug, give preference to the combined variants, where both potassium and magnesium are simultaneously contained. Trace elements do not contradict each other, but rather harmoniously interact. Use the above tips and recommendations to permanently get rid of the problems associated with the deficiency of vital elements - potassium and magnesium.

The normal functioning of the body is ensured by the systematic entry of certain elements into it. A very important role among them is played by minerals, as well as vitamins. It is these particles that are responsible for the normal passage of all metabolic processes, as well as for the production of enzymes and hormones, the functioning of organs and systems, the production of blood and much more. However, with the help of food it is not always possible to cover all the needs of the body in these substances. And here come to the aid of various multivitamin and polymineral pharmaceutical drugs. Which of them are able to saturate our body with calcium and magnesium?

How to recognize the deficit?

In order to recognize the lack of these mineral elements in the body, you should pay attention to your well-being. A blood test is not able to show a clear picture of the content of magnesium or calcium in the blood, so you should familiarize yourself with the symptoms of their lack. So a lack of calcium leads to muscle cramps, which most often bother the patient at night. The person also suffers from increased nervous excitability. Symptoms of disturbed nervous regulation of the internal organs may be observed. Children often develop laryngeal spasms that can be triggered by exposure to external factors — cold, excitement, and sudden arousal. Spasms of the bronchi can significantly relieve asthma attacks, and spasms of the muscles of the stomach provoke vomiting, constipation and diarrhea. In addition, lack of calcium can cause spasm of the bladder, resulting in pain in the kidneys, or spasm of the gallbladder, which causes pain in the liver. Also, such a deficiency often causes obvious PMS in women and provokes severe discomfort and pain during menstruation.

If we talk about magnesium deficiency, it is also quite common. This problem is manifested by a feeling of chronic fatigue and rather rapid fatigue, the person feels heaviness in the body, and in the mornings remains broken even after prolonged sleep. Magnesium deficiency often causes hair loss, brittle nails and dental caries. Such a deficiency is also manifested by irritability and anxiety, provokes tearfulness, depression and unexplained bouts of anguish. In this case, patients may complain of violations of the quality of night rest, they are worried about nightmares, excessive sweating at night.

Dizziness or headaches also become a frequent symptom of magnesium deficiency. In this case, the person also loses the ability to concentrate, his attention weakens and his memory deteriorates.

Drugs

In order to choose the most suitable drug for you to saturate the body with calcium and magnesium, it is worth remembering about some of the features of these substances. So calcium is quite difficult to digest by our body, and to fully absorb its drug, it must also contain vitamin D3, the latter must be in a water-soluble form. The content of calcium and magnesium in the selected composition should be 2: 1, only in this case, both of them will really assimilate as much as possible.

An excellent variant of such a medicinal composition is the drug under the name Ortho Calcium + Magnesium. This medicine is produced by the world-famous ORTO company from raw materials supplied from Sweden, Switzerland, and also Germany. In addition to calcium and magnesium, there is also vitamin D3, as well as vitamins C, B6 and K1, as part of such a medicine. Also, this tool fills the body with zinc, manganese and citrates.

Vitrum Osteomag is a source of calcium and magnesium, and also supplies vitamin D3, zinc, copper and boron to our bodies.

The composition of Calcium Advance, in addition to calcium and magnesium, also contains zinc, manganese, copper and boron, besides it also contains vitamin D3.

Regimen

If vitamins containing magnesium and calcium are taken in order to prevent a shortage of the elements already described, it is customary to consume one tablet per day. However, with an existing deficiency, the dosage is selected by a doctor and can be increased to two tablets or even more, depending on the individual characteristics of the patient.

Possible side effects

In certain cases, consuming this type of multivitamin supplement causes side effects. So they can provoke constipation and bloating, as well as cause nausea and mild pain in the abdomen.

An overdose of medicinal formulations can cause headaches, appetite suppression, as well as nausea and even vomiting. In certain cases, patients with excessive consumption complain of severe weakness and dizziness. In this case, they should drink plenty of ordinary pure water and reduce the consumption of foods containing calcium.

Contraindications

It is worth considering that such medicinal formulations should not be taken during the period of gestation of the baby or in the implementation of breastfeeding without prior consultation with a specialist. In addition, such drugs are not prescribed for urolithiasis (with the formation of phosphorus-calcium stones) or for renal failure. Calcium preparations are contraindicated in case of excessive calcium in the blood. Of course, another contraindication is the individual intolerance of some components of the selected medication.


30A-------------------xx

Nature Made? High Potency Magnesium 400 Mg, 60-Count

Nature Made? High Potency Magnesium 400 Mg, 60-Count

Can magnesium preparations reduce the risk of urolithiasis recurrence?

Magnesium ranks fourth among the body cations and second after potassium among intracellular cations. The total magnesium of the body is approximately 2000 meq or 25 g. Similarly, calcium contains only a small portion of magnesium (about 1%) in extracellular fluid. Approximately 60% of the total magnesium of the human body is found in bone tissue, where most of it is associated with apatite crystals. A significant amount of magnesium in bone tissue is represented as ions that can actively exchange with serum ions.

Approximately 360 mg (15 mmol) of magnesium is supplied daily with food. A significant portion of magnesium is supplied by green vegetables. The minimum intake of magnesium in an amount of 0.3 mEq / kg body weight is necessary to maintain magnesium balance in humans. Approximately one third of the total magnesium ingested with food is excreted in the urine, the rest is excreted.

Thus, when on a normal diet containing about 360 mg of magnesium, 30-40% of the magnesium ingested with food is absorbed mainly in the small intestine. A small amount of magnesium, about 40 mg (1.7 mmol) is secreted in the gastrointestinal tract in the composition of the digestive juices and about 20 mg (0.8 mmol) is absorbed back into the large intestine [1].

Absorption of dietary calcium from the gastrointestinal tract is an active process, whereas magnesium is absorbed mainly due to ionic diffusion, and also due to a simple reverse flow of water, without the participation of cellular ionic pumps and membrane transport proteins. Hypermagnesemia inhibits the production of parathyroid hormone, and acute hypomagnesemia stimulates the secretion of this hormone, which increases the absorption of magnesium from the gastrointestinal tract [1].

At the same time, clinical observations show that the majority of patients with chronic magnesium deficiency, manifested by hypomagnesemia and hypocalcemia, have normal or slightly reduced levels of parathyroid hormone, indicating an inadequately low parathormone secretion under conditions of chronic magnesium deficiency [24].

The kidneys filter approximately 2 g of magnesium per day, about 100 mg is excreted in the urine. Unlike other ions, magnesium reabsorption in the kidneys does not occur in the proximal tubules, but in the thick ascending portion of the loop of Henle, where up to 60-70% of magnesium is reabsorbed [5, 6].

Thus, most of the filtered magnesium is reabsorbed and only about 5% of it is excreted in the urine. In a state of magnesium deficiency, the kidneys are able to reduce the amount of magnesium excreted in the urine to 0.5% or less of the filtered amount. On the other hand, during the infusion of magnesium or in patients with advanced renal failure, the kidneys are capable of removing 40-70% of the filtered amount of magnesium. The concentration of magnesium in the blood plasma is the main physiological regulator of its excretion in the urine [5, 6].

Hypermagnesemia inhibits the renal reabsorption of magnesium (and calcium) in the loop of Henle, while hypomagnesemia stimulates this process, thereby preventing the loss of magnesium from the body. In turn, hypercalcemia also inhibits the reabsorption of magnesium (and calcium), leading to hypermagniuria and hypercalciuria. It is noted that metabolic alkalosis increases, and metabolic acidosis, hypokalemia and phosphate loss inhibit magnesium reabsorption in the kidneys [5].

The amount of excreted urine calcium is under the regulatory influence of a whole complex of factors. These include calciotropic hormones, the volume of extracellular fluid, the state of acid-base balance, the concentration of various ions in the urine and blood plasma [7].

Hypercalciuria, as one of the main risk factors for urolithiasis, is found quite often in patients with urolithiasis and patients with osteoporosis [8].

The concentration of magnesium ions in the urine, as well as the acidity of urine, can affect the excretion of calcium in the urine. However, the mechanisms explaining this relationship are still poorly understood.

The first description of the effect of magnesium on calciuria was made back in 1909 by Mendel and Benedict [9]. They found an increase in calcium excretion and a decrease in its concentration in the intestinal contents during the parenteral administration of magnesium to various types of experimental animals. Similar results were later obtained in the treatment of magnesium sulfate in women with preeclampsia and in healthy individuals after the administration of this drug [10, 11]. Moreover, as was shown, the calciuric effect is associated not with sulfate, but with magnesium ion [12].

Experimental studies have confirmed increased calciuria after intravenous administration of magnesium solutions in dogs with normal and impaired renal function [13]. The use of micro-puncture technique in an experiment on rats treated with infusions of magnesium chloride made it possible to establish the involvement of the loop of Henle in the development of calciuria induced by magnesium ions [14, 15].

Another important metabolic factor that can affect calcium excretion is urine pH. It is known that a large amino acid load caused by a high intake of animal protein in food decreases the urine pH and increases calcium excretion [1618]. In contrast, alkalinization of urine with potassium preparations (bicarbonate or potassium citrate) reduces urinary calcium excretion [19, 20].

There are data indicating that an increase in urinary acidity increases the excretion of calcium in the urine due to proton inhibition of the calcium channels of the renal epithelium TRPV5 and TRPV6, which are responsible for the reabsorption of calcium in the distal nephron [21, 22]. Magnesium ions are believed to act on the same links in the regulation of calcium excretion. It is noted that micromolar concentrations of magnesium are also able to inhibit the activity of calcium channels TRPV5 [23, 24].

The possibility of the clinical use of magnesium preparations in calcium urolithiasis continues to be discussed.

Some literature data indirectly indicate a possible protective effect of magnesium against calcium urolithiasis. So, it is known that magnesium is able to form complexes with oxalates in the intestinal lumen and urine [25-28], inhibit the formation of calcium oxalate crystals in vitro [25, 29, 30] and increase the excretion of citrates with urine, in the case of magnesium in the form of citrate salts [31].

This, apparently, can explain the confidence of many clinicians that magnesium is an effective means of preventing the formation of calcium urinary stones in patients with urolithiasis. For example, some authors suggest using the ratio of urinary concentrations of magnesium and calcium (Mg / Ca index) as an indicator of the risk of stone formation and stone recurrence [32-34]. In their opinion, the concentration ratio in the urine Mg / Ca below 0.7 indicates an increased risk of stone formation.

However, when examining 155 patients with non-infectious recurrent oxalate urolithiasis, no decrease in magnesium excretion in the urine was found [35]. Similar data were obtained in the study of the concentration of magnesium in the urine of healthy individuals and patients with recurrent form of calcium urolithiasis [36].

In addition, the results of a survey of 2147 patients with stones represented by pure calcium oxalate showed that only 11% of patients had reduced daily excretion of magnesium, whereas in the remaining 89% of patients this indicator was within normal values. At the same time, the frequency of recurrence of stones in the group of patients with hypomagniuria showed only a weak statistically insignificant tendency to increase compared with the group of patients with normagniuria [37]. As a result, a positive clinical effect, depending on the concentration in the urine of magnesium, was not achieved.

Thus, there is no convincing evidence that magnesium deficiency is one of the main reasons for the development of calcium oxalate urolithiasis.

Particularly noteworthy is the analysis of the results of 17 clinical trials to study the efficacy of magnesium and potassium salts using the Urolithiasis Registry Database of the Southwestern Medical Center of the University of Texas [19, 25, 26, 38-46].

Healthy volunteers and patients with urolithiasis who had no signs of magnesium deficiency, hypomagnemia, acid-base balance disorders, pathologically altered levels of potassium and blood calcium participated in the tests. In a group of 4 clinical trials (group I, average observation time 2 weeks, 47 people), patients who took magnesium oxide (MgO) or magnesium citrate (Mg 3 Citrate 2 ), high excretion of urine calcium, magnesium with a slight change the pH of urine (table 1). In a group of 8 clinical trials (group II, average observation time 2 weeks, 89 people), patients took potassium bicarbonate (KHCO 3 ) or potassium citrate (KB 3 Citrate). At the same time, the opposite dynamics was observed: pronounced alkalinization of urine, the absence of increased excretion of magnesium and a marked decrease in hypercalciuria. In a group of 5 clinical trials (group III, average follow-up time 2.6 weeks, 102 people), patients took the combined drug potassium magnesium citrate (K 4 MgCitrate 2 ). Taking the drug increased the excretion of magnesium in the urine, but less pronounced than in group I of the tests and caused alkalinization of the urine to the same extent as was observed in group II of the tests. Increased calcium excretion was not statistically significant.

These data suggest that magnesium preparations in the form of magnesium oxide (MgO) or magnesium citrate (Mg 3 Citrate 2 ) are capable of inducing hypercalcemia in patients with urolithiasis, while potassium citrates have the opposite effect. Experimental studies have shown that the calciuric effect of magnesium is associated with inhibition of calcium reabsorption in the distal convoluted nephron tubules, possibly due to inhibition of the apical calcium channels TRPV5 and not dependent on the effect of parathyroid hormone [47].

Obviously, the use of magnesium or its citrates can not be recommended as monotherapy for recurrent calcium urolithiasis.While co-administration of magnesium and potassium citrates significantly reduced the incidence of calcium-oxalate urolithiasis recurrence, as was shown in a 3-year randomized study in 64 patients [48].

Idiopathic recurrent calcium urolithiasis is a disease with unclear etiology and pathogenesis. The role of magnesium in stone formation in these patients remains poorly understood. The results of a simultaneous examination of 284 patients (cross-sectional study) with idiopathic recurrent calcium urolithiasis (IRKU) showed that increased magnesium excretion is associated with increased excretion of calcium, potassium, sodium, protein, and, to a lesser extent, citrates. At the same time, in patients with hypermagniuria, there was a higher urinary supersaturation in hydroxyapatite and a clinically more active form of recurrence of urolithiasis [49]. Thus, increased excretion of magnesium in the urine is not a protective factor in relation to the development of calcium urolithiasis.

In another work [50], it was noted that in 12 men with IRKU, serum levels of total magnesium and its fractions (free, ionized and bound to proteins) did not differ from healthy men in the control group. At the same time, in patients the level of serum albumin and magnesium in erythrocytes was lower than in the control, and the indices of excretion of magnesium in the urine corresponded to those of the control group. The ratio in the urine magnesium / creatinine in patients also did not differ from healthy individuals. However, the urine of patients had higher concentrations of protein, glucose and pH.

It should be noted that urinary supersaturation with respect to calcium oxalate in patients with IRKU was lower (1.5 vs 2.2), and with respect to hydroxyapatite it was higher (3.3 vs 1.8) than in healthy individuals. The latter deserves attention in the aspect that hydroxyapatite crystals are able to induce heterogeneous nucleation of calcium oxalate crystals [51], thereby promoting further crystal growth and stone formation. This indicates the involvement of other pathogenesis mechanisms of the IRKU, which are not directly related to the concentration of magnesium in the urine.

It is believed that with IRKU, the role of urine Mg deficiency as a risk factor for the formation of calcium stones can be questioned or completely denied. However, the noted link between intracellular Mg deficiency and tubular functional disorders, in the form of impaired glucose reabsorption, proteins and urine acidification, indicates the need for further study of this issue.

To increase the excretion of magnesium in the urine is usually used such drugs as magnesium oxide or hydroxide, potassium magnesium citrate and magnesium aspartate. Increasing the concentration of magnesium in the urine leads to a decrease in the value of the product of the ionic activity of calcium oxalate, inhibition of the growth of calcium phosphate crystals, reducing the risk of formation of brushite [52].

However, according to the latest Urolithiasis Guidelines, adopted in 2011 by the European Urological Association, there is currently no convincing evidence to recommend magnesium preparations as monotherapy to prevent the formation of calcium stones [52]. In most of the studies on the clinical use of magnesium preparations, physicochemical and biochemical changes in the urine of patients with urolithiasis were investigated [25, 29-31] without evaluating long-term results in the form of stone recurrence rate.

There are only two randomized controlled studies of the clinical effect of magnesium in urolithiasis. One study used magnesium hydroxide versus a control group that received a placebo [53]. In another study, magnesium oxide was used in comparison with a control group that did not receive any treatment [54]. None of these studies showed a statistically significant effect on the formation of urinary stones, despite the long observation period of 4 and 3 years, respectively.

The positive effect of magnesium was described in earlier studies [55, 56], but is not confirmed in controlled studies in recent years [57].

In these works, magnesium was used as an oxide or hydroxide. Obviously, the absence of a visible anti-relapse effect of these drugs suggests that magnesium itself cannot be used as a monotherapy for calcium stones. Recently, it has been increasingly used in the form of citric acid salts — magnesium citrate (K 3 Citrate) or potassium magnesium citrate (K 4 MgCitrate 2 ), given the pronounced inhibitory effect of citrate ion on calcium oxalate and calcium phosphate crystal formation [ 29-31].

Experimental laboratory tests conducted in vitro in artificial or human urine show that magnesium exhibits its inhibitory properties with respect to the formation of calcium oxalate crystals only at high concentrations significantly different from physiological values ​​[37, 5863]. Moreover, it has been shown that the inhibitory effect of magnesium citrate on the formation of calcium oxalate crystals is due only to citrate, and not to magnesium ions [64].

CONCLUSION

The results of clinical trials indicate an increase in calciuria under the influence of magnesium preparations (magnesium oxide, magnesium hydroxide, magnesium citrate) used as monotherapy without potassium citrates. However, simultaneous alkalinization of urine can reduce the undesirable effect of hypercalciuria [46]. It can be assumed that for the prevention of recurrence of calcium stones, magnesium preparations should be used not as monotherapy, but in combination with pyridoxine, potassium alkaline citrates and / or thiazide diuretics. This should be the goal of further clinical trials.


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Solgar Magnesium Citrate, Highly Absorbable, Promotes Healthy Bones, Non-GMO, Suitable for Vegans, 120 Tablets

Solgar Magnesium Citrate, Highly Absorbable, Promotes Healthy Bones, Non-GMO, Suitable for Vegans, 120 Tablets

Is magnesium a vital mineral?

Do you know that magnesium is the second element after vitamin D , the lack of which is observed in most people, and this is in developed countries!

This is very regrettable, given that magnesium is associated with many biochemical and enzymatic processes. He takes part in more than 300 enzymatic reactions, for example: the transfer of important genetic information, the assimilation of essential vitamins and minerals, the activation of amino acids and others. Energy production, regulation of blood pressure, glucose levels, the work of muscles and nerves - all this relates to the sphere of functioning of magnesium.

Experts say that in adults who consume magnesium in smaller amounts (than the daily daily dosage provides for) in quantity, symptoms of inflammation appear more often. In turn, health problems arise - diseases of the cardiovascular system, diabetes and cancer. Also, a low level of magnesium in the body can lead to osteoporosis.
Why does magnesium deficiency occur?

Nearly 80% of people suffer from a shortage of vital minerals - in particular magnesium. Excessive cultivation of agricultural products and the use of pesticides affect the soil. As a result, the soil becomes poorer and loses important minerals. During heat treatment at high temperatures, products lose their nutritional value.

It is difficult for modern man today to get magnesium, but it is very easy to waste. Stress, alcohol, coffee, excess sweets, antibiotics, diuretics, laxatives, heart medications, a lack of vitamin E. All this leads to the removal of magnesium from the body.
The most visible signs of magnesium deficiency in the body are:

cramps in the legs - painful cramps, the so-called. "Goosebumps" on the hands and feet,
muscle tension in the body
twitching century,
constant fatigue and nervousness.

In addition, caries, slowing the growth of the jaw, which is not enough space for the teeth. Muscle relaxation and growth also depend on magnesium.
Magnesium Sources

The best sources of natural magnesium are whole grains, nuts, lettuce and sprouts.

300 mg of magnesium is contained, for example, in:
* 60 g cocoa powder,
* 65 grams of wheat bran,
* 110 g almonds,
* 165 g hazelnuts,
* 450 grams of milk chocolate
* 1.3 kg broccoli
* 1.4 kg of lettuce and iceberg,
* 2 kg of Chinese cabbage.
The relationship of the nervous system and magnesium

Other symptoms may indicate a lack of magnesium in the body. They are related to the functioning of the nervous system:

anxiety, panic attacks, irritability;
agoraphobia (fear of open large spaces and squares);
fatigue and exhaustion;
headaches and migraines;
depression, excessive sensitivity to light and loud sounds;
restless legs syndrome;
constipation, high blood pressure, arrhythmia and palpitations;
any sleep disorders.

Insomnia.
The best forms of magnesium and their absorption by the body

On the Estonian version of the Vitamiini ABC website and English-language resources comparing various forms of magnesium and their characteristic properties, citrate, gluconate and lactate (glycinate) are considered the best from the point of view of absorption. For clarity, I will give here the other names of magnesium glycinate : magnesium diglycinate, magnesium bisglycinate, magnesium bisglycinate chelate. All names actually mean the same thing. The Vitamiini ABC page states that 1 g of magnesium glycinate contains 100 mg or 10% of elemental magnesium. When the drug with magnesium glycinate contain up to 14% elemental magnesium, it is considered high-quality. Ecosh magnesium glycinate products have an absolute magnesium content of 18%, which is considered to be a very high percentage.

Magnesium oxide / oxalate is the worst absorbed material, which is a very inexpensive raw material and the content of elemental magnesium in it is quite high - 58%, but only 4% of this amount can be absorbed by the body. In addition, prolonged use of magnesium oxide pollutes the kidneys. In pharmacies in Estonia, predominantly magnesium oxide preparations are presented. They can also cause diarrhea. The citrate form also has a laxative effect due to the addition of citric acid.
What elements contribute to the absorption of magnesium?

Although magnesium is also absorbed by itself, some vitamins or minerals can contribute to this. Such elements are vitamins of group B , in particular vitamins B6, C and D, as well as calcium, potassium, sodium, etc. Therefore, it is better to take magnesium with food so that all other necessary substances are also available. Vitamin B6 helps determine how much magnesium is absorbed by the cells. Bioactive forms of vitamins, such as pyridoxine hydrochloride (B6) and L-magnesium ascorbate ( vitamin C ) were added to the magnesium glycinate Ecosh supplement for better absorption of magnesium.

There is no data on magnesium overdose, but according to the literature, high doses are safe. The recommended dosage for therapeutic purposes is from 800 to 3000 mg per day. For example, the ratio of magnesium to calcium in the body should be 8: 1, or at least 4: 1. The inverse ratio is promoted when there should be more calcium in the body. By the way, without magnesium, calcium doesn't even reach the bones. In addition, it clogs arteries and tissues. Daily intake of magnesium should be 375 mg.
The body needs magnesium to:

bones (about 70% of the magnesium found in the body is in the bones);
protein production;
release muscle energy;
body temperature adjustments;
exchange of calcium, phosphorus, potassium, zinc and sodium;
better digestibility of vitamins of groups B , C, D and E;
regulate heartbeat;
regulating blood circulation to work the heart muscles;
releasing energy and working muscles and nerves
at least 300 basic enzymatic reactions,
effects on carbohydrate metabolism and activation of amino acids.

According to studies , magnesium glycinate is very well suited to those with intestinal disorders (eg, diarrhea) or an operation to reduce the intestinal tract. The reason for this is its good digestibility in different parts of the intestine.

Magneesium

Magnesium gluconate and magnesium glycinate are considered the best forms to use in the event of a serious magnesium deficiency. Magnesium glycinate soothes, relaxes muscles, provides good sleep (makes drowsy). Poetmu, glycinate magnesium is better to take before going to bed for 30 min -1 h.


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Natural Vitality Natural Calm Anti Stress Drink 30 count Raspberry Lemon flavor

Natural Vitality Natural Calm Anti Stress Drink 30 count Raspberry Lemon flavor

The Importance of Magnesium-B6 to Human

Magnesium B6 with benefits for your health and nervous system
The human body contains many chemicals that can ensure its smooth operation. A major contribution to the normal functioning of all systems and organs is made by such an important macro element as magnesium.

He is directly involved in processes such as protein synthesis, energy production, regulation of cholesterol levels.

In addition, it is responsible for the normal functioning of the heart muscle and circulatory system, and also ensures the absorption of calcium.

Magnesium enters the body with food, but in the conditions of modern life it is not always possible to eat properly, and thereby maintain the optimal amount of nutrients.

Constant stress, bad habits, hard physical and mental work - all this can cause a deficiency of this macrocell, which is usually accompanied by the following symptoms:

• increased fatigue;
• Irritability, anxiety and other nervous disorders;
• Dizziness and severe headaches;
• Heart arythmy;
• Muscle weakness, convulsions;
• Gastrointestinal dysfunction;
• Insomnia;
• High blood pressure.
• Painful periods in women;
• Worsening of hair, brittle nails.

If you have the above symptoms, it makes sense to think about taking special vitamin complexes, among which Magne B6 forte is considered the most useful.


A bunch of magnesium and vitamins B6 - benefits to the body
Magne B6 pills or capsules are an excellent supplement, thanks to which you can completely compensate for the lack of this macro element.

Vitamin B6 contributes to a better absorption of the macro element Mg and enhances its action, moreover, it is extremely positive effect on the nervous system and metabolic processes.

The question of taking such vitamin-mineral complexes most often arises in such conditions as:

• Heart failure;
• High blood pressure;
• High cholesterol;
• Unreasonable mood swings;
• Nervous irritability;
• Cardiopalmus;
• Constant fatigue;
• Muscle cramps.

Supplements such as magnesium b6 forte or magnesium b6 anti-stress can benefit both women and men. Representatives of the strong half of humanity must monitor the level of this substance in the body and, if necessary, resort to additional intake, because its deficiency is the cause of the decrease in the main male hormone - testosterone. This, in turn, can lead to a significant deterioration in men's health.

Products magnesium B6 can bring tangible benefits and women's health. They will help alleviate the symptoms of PMS, menopause, as well as the pronounced symptoms of toxicosis during pregnancy. Often, future mothers learn about magnesium deficiency when they experience nighttime cramps. This element is able to provide a safe course of pregnancy. But, in this position, self-treatment should be avoided and before taking any dietary supplements it is best to consult with a gynecologist.

The daily need for macronutrient in adults usually ranges from 300 to 350 mg, in some cases it can be increased.

If you have decided to take fortified complexes, such as Magnesium b6 antistress or other similar drugs, then it is best to drink them in courses. These supplements are able to improve the physical and emotional state and return the person to a normal life.
How is Magne B6 useful in sports and bodybuilding?
Due to its unique properties, Magne B6 is one of the most sought-after sports supplements. In bodybuilding and any other sport, the element Mg is valued for the fact that it stimulates the synthesis of proteins, and also contributes to the development of a large amount of energy. Athletes taking magnesium-containing drugs have noted an increase in muscle mass, an increase in strength and endurance, and an increase in the effectiveness of the training process.

In addition, professional athletes claim that such vitamin-mineral complexes help to get rid of muscle cramps, which often occur in athletes exposed to serious physical exertion.
During the preparation for the competition and during their holding, such additives allow the athlete to successfully cope with numerous stressful situations.

They normalize sleep, which usually plays an important role in the recovery process, and also reduces irritability and prevents the development of chronic fatigue syndrome.
The role of magnesium-containing complexes in combination with B6 cannot be overestimated, since they allow the athlete:
• Improve muscle contractility;
• Significantly increase energy levels and endurance;
• Speed ​​up the recovery process after a workout;
• Faster muscle building.

The most popular magnesium-containing complexes from the best brands.

To date, the choice of such products is quite wide. But how not to be mistaken with the choice and purchase really high-quality products?
If you decide to buy Magne B6 for yourself, you should pay attention to the following products:
• Chela-Mag B6 Forte Olimp Nutrition is a highly effective product from a well-known Polish manufacturer, the main component of which is an amino acid magnesium chelate in the dosage of 1390 milligrams in one capsule. It has a high rate of absorption and is ideal for people with excessive needs for this macrocell.

The composition of the product is supplemented with pyridoxine or vitamin B6, which enhances the action of the main component and plays an important role in metabolic processes. Package contains 60 capsules.

• Magne-100 Sport Trec Nutrition is another unique complex from a popular Polish brand, thanks to which you can easily meet the daily need for these two vital substances.

Available in the form of capsules, which are easily and quickly absorbed in the body. The product is ideal for athletes, people leading an active lifestyle, as well as all those who need an additional intake of magnesium-containing vitamins.

• Solgar's Magnesium with Vitamin B6 is a dietary supplement in the form of tablets that combines two natural ingredients that play a key role in maintaining the overall health of the whole body. Does not contain gluten, wheat and dairy products. Ideal for vegans and vegetarians.

Thanks to this complex, you will be able to maintain the normal functioning of the nervous and cardiovascular systems, as well as to increase the level of energy necessary to maintain all the vital functions of the body. This product is of first-class quality and high efficiency.


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